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@ARTICLE{Gao:136718,
      author       = {X. Gao$^*$ and H. Brenner$^*$ and B. Holleczek and K.
                      Cuk$^*$ and Y. Zhang$^*$ and A. Anusruti$^*$ and Y. Xuan$^*$
                      and Y. Xu and B. Schöttker$^*$},
      title        = {{U}rinary 8-isoprostane levels and occurrence of lung,
                      colorectal, prostate, breast and overall cancer: {R}esults
                      from a large, population-based cohort study with 14 years of
                      follow-up.},
      journal      = {Free radical biology and medicine},
      volume       = {123},
      issn         = {0891-5849},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-01156},
      pages        = {20 - 26},
      year         = {2018},
      abstract     = {Urinary 8-isoprostane is an established biomarker for lipid
                      peroxidation. However, the association between its
                      pre-diagnostic levels and cancer incidence has rarely been
                      evaluated.8793 older adults from the German ESTHER cohort
                      were followed up for cancer incidence by cancer registry
                      data. A directed acyclic graph was utilized to identify
                      potential confounders. Multivariate Cox regression models
                      were applied to estimate hazard ratios (HRs) and $95\%$
                      confidence intervals $(95\%$ CI).During 14-year follow-up,
                      1540 incident cancer cases, including 207 lung, 196
                      colorectal, 218 breast and 245 prostate cancer cases were
                      detected. 8-isoprostane concentrations were positively
                      associated with lung cancer, but not with cancer at the
                      other sites. The HR $(95\%$ CI) for the association with
                      lung cancer was 1.61 (1.10, 2.34) for comparison of the top
                      with bottom tertile in total population. The association of
                      8-isoprostane levels with lung cancer persisted after the
                      adjustment for smoking and other potential confounders and
                      was multiplicative to the effect of smoking. However,
                      8-isoprostane levels did not improve lung cancer prediction
                      when added to a model containing age, sex and smoking. A
                      protective association of increasing 8-isoprostane levels
                      was observed for prostate cancer incidence but this
                      association was only statistically significant among current
                      smokers.Our findings suggest that lipid peroxidation is
                      involved in the development of lung cancer. However, high
                      oxidative stress may be a protective factor for prostate
                      cancer, especially among current smokers.},
      cin          = {C070 / G110 / L101},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29778463},
      doi          = {10.1016/j.freeradbiomed.2018.05.065},
      url          = {https://inrepo02.dkfz.de/record/136718},
}