000136721 001__ 136721
000136721 005__ 20240229105055.0
000136721 0247_ $$2doi$$a10.1038/s41424-018-0035-2
000136721 0247_ $$2pmid$$apmid:29976921
000136721 0247_ $$2pmc$$apmc:PMC6033915
000136721 0247_ $$2altmetric$$aaltmetric:45332609
000136721 037__ $$aDKFZ-2018-01159
000136721 041__ $$aeng
000136721 082__ $$a610
000136721 1001_ $$0P:(DE-He78)6d4d6a0e2d726f899086ca98cd560922$$aGies, Anton$$b0$$eFirst author$$udkfz
000136721 245__ $$aDirect comparison of ten quantitative fecal immunochemical tests for hemoglobin stability in colorectal cancer screening.
000136721 260__ $$aLondon$$bNature Publ. Group$$c2018
000136721 3367_ $$2DRIVER$$aarticle
000136721 3367_ $$2DataCite$$aOutput Types/Journal article
000136721 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1659699847_13807
000136721 3367_ $$2BibTeX$$aARTICLE
000136721 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000136721 3367_ $$00$$2EndNote$$aJournal Article
000136721 520__ $$aTo systematically investigate and directly compare, for the first time, the sample stability of a large number of quantitative fecal immunochemical tests (FITs) at different storage conditions.Stool samples were obtained from participants of the German screening colonoscopy program between 2005 and 2010. After an initial FIT-based hemoglobin (Hb) measurement, stool samples were kept frozen at -80 °C until analysis. Twenty randomly selected participants with initial measurements ranging from 10 to 100 μg Hb/g feces were included. Ten quantitative FITs were investigated in parallel. A defined stool amount was extracted using each manufacturer's brand-specific fecal sampling device and stored at 5 °C, 20 °C, and 35 °C, respectively. After 1, 4, 5, and 7 days, the samples were analyzed blinded. Median fecal Hb concentrations and positivity rates were calculated.Mean age of the participants was 67 years (range: 56-80 years) and 60% were male. The most advanced finding at screening colposcopy was advanced adenoma in five and non-advanced adenoma in eight cases. Hyperplastic polyps were found in two participants and five participants were without any findings. At 5 °C storage temperature, almost all FITs showed fairly stable results throughout the 7-day observation period. At 20 °C, most FITs still showed fairly stable results over 4 days, whereas positivity rates significantly declined from day 4 on for most FITs at 35 °C. Major differences regarding the sample stability between FITs were observed.FIT-specific Hb decay according to ambient temperature and time period between sampling and test evaluation requires careful consideration in the design of FIT-based screening programs.
000136721 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000136721 588__ $$aDataset connected to CrossRef, PubMed,
000136721 7001_ $$0P:(DE-He78)0a8ada1f5d2ea05fc3af10cd808bfa9a$$aCuk, Katarina$$b1$$udkfz
000136721 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b2$$udkfz
000136721 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b3$$eLast author$$udkfz
000136721 773__ $$0PERI:(DE-600)2581516-7$$a10.1038/s41424-018-0035-2$$gVol. 9, no. 7, p. 168$$n7$$p168$$tClinical and translational gastroenterology$$v9$$x2155-384X$$y2018
000136721 909CO $$ooai:inrepo02.dkfz.de:136721$$pVDB
000136721 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6d4d6a0e2d726f899086ca98cd560922$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000136721 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0a8ada1f5d2ea05fc3af10cd808bfa9a$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000136721 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000136721 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000136721 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000136721 9141_ $$y2018
000136721 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCLIN TRANSL GASTROEN : 2015
000136721 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000136721 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000136721 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000136721 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000136721 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000136721 915__ $$0LIC:(DE-HGF)CCBYNCNDNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND (No Version)$$bDOAJ
000136721 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000136721 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000136721 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000136721 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000136721 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000136721 9201_ $$0I:(DE-He78)G110-20160331$$kG110$$lPräventive Onkologie$$x1
000136721 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x2
000136721 980__ $$ajournal
000136721 980__ $$aVDB
000136721 980__ $$aI:(DE-He78)C070-20160331
000136721 980__ $$aI:(DE-He78)G110-20160331
000136721 980__ $$aI:(DE-He78)L101-20160331
000136721 980__ $$aUNRESTRICTED