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@ARTICLE{Gies:136721,
      author       = {A. Gies$^*$ and K. Cuk$^*$ and P. Schrotz-King$^*$ and H.
                      Brenner$^*$},
      title        = {{D}irect comparison of ten quantitative fecal
                      immunochemical tests for hemoglobin stability in colorectal
                      cancer screening.},
      journal      = {Clinical and translational gastroenterology},
      volume       = {9},
      number       = {7},
      issn         = {2155-384X},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2018-01159},
      pages        = {168},
      year         = {2018},
      abstract     = {To systematically investigate and directly compare, for the
                      first time, the sample stability of a large number of
                      quantitative fecal immunochemical tests (FITs) at different
                      storage conditions.Stool samples were obtained from
                      participants of the German screening colonoscopy program
                      between 2005 and 2010. After an initial FIT-based hemoglobin
                      (Hb) measurement, stool samples were kept frozen at
                      -80 °C until analysis. Twenty randomly selected
                      participants with initial measurements ranging from 10 to
                      100 μg Hb/g feces were included. Ten quantitative FITs
                      were investigated in parallel. A defined stool amount was
                      extracted using each manufacturer's brand-specific fecal
                      sampling device and stored at 5 °C, 20 °C, and
                      35 °C, respectively. After 1, 4, 5, and 7 days, the
                      samples were analyzed blinded. Median fecal Hb
                      concentrations and positivity rates were calculated.Mean age
                      of the participants was 67 years (range: 56-80 years) and
                      $60\%$ were male. The most advanced finding at screening
                      colposcopy was advanced adenoma in five and non-advanced
                      adenoma in eight cases. Hyperplastic polyps were found in
                      two participants and five participants were without any
                      findings. At 5 °C storage temperature, almost all FITs
                      showed fairly stable results throughout the 7-day
                      observation period. At 20 °C, most FITs still showed
                      fairly stable results over 4 days, whereas positivity rates
                      significantly declined from day 4 on for most FITs at
                      35 °C. Major differences regarding the sample stability
                      between FITs were observed.FIT-specific Hb decay according
                      to ambient temperature and time period between sampling and
                      test evaluation requires careful consideration in the design
                      of FIT-based screening programs.},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29976921},
      pmc          = {pmc:PMC6033915},
      doi          = {10.1038/s41424-018-0035-2},
      url          = {https://inrepo02.dkfz.de/record/136721},
}