000136738 001__ 136738
000136738 005__ 20240229105056.0
000136738 0247_ $$2doi$$a10.1371/journal.pone.0199350
000136738 0247_ $$2pmid$$apmid:29928061
000136738 0247_ $$2pmc$$apmc:PMC6013205
000136738 0247_ $$2altmetric$$aaltmetric:44105381
000136738 037__ $$aDKFZ-2018-01176
000136738 041__ $$aeng
000136738 082__ $$a500
000136738 1001_ $$aHuhn, Stefanie$$b0
000136738 245__ $$aCoding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer.
000136738 260__ $$aLawrence, Kan.$$bPLoS$$c2018
000136738 3367_ $$2DRIVER$$aarticle
000136738 3367_ $$2DataCite$$aOutput Types/Journal article
000136738 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1659950029_8495
000136738 3367_ $$2BibTeX$$aARTICLE
000136738 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000136738 3367_ $$00$$2EndNote$$aJournal Article
000136738 520__ $$aNod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort of sporadic colorectal cancer (CRC) (1237 cases, 787 controls) for their association with CRC risk and survival. Five SNPs were found to be associated with CRC risk and eight with survival at 5% significance level. In a replication analysis using data of two large genome-wide association studies (GWASs) from Germany (DACHS: 1798 cases and 1810 controls) and Scotland (2210 cases and 9350 controls) the associations found in the Czech discovery set were not confirmed. However, expression analysis in human gut-related tissues and immune cells revealed that the NLRs associated with CRC risk or survival in the discovery set were expressed in primary human colon or rectum cells, CRC tissue and/or cell lines, providing preliminary evidence for a potential involvement of NLRs in general in CRC development and/or progression. Most interesting was the finding that the enigmatic development-related NLRP5 (also known as MATER) was not expressed in normal colon tissue but in colon cancer tissue and cell lines. Future studies may show whether regulatory variants instead of coding variants might affect the expression of NLRs and contribute to CRC risk and survival.
000136738 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000136738 588__ $$aDataset connected to CrossRef, PubMed,
000136738 7001_ $$ada Silva Filho, Miguel I$$b1
000136738 7001_ $$aSanmuganantham, Tharmila$$b2
000136738 7001_ $$aPichulik, Tica$$b3
000136738 7001_ $$0P:(DE-He78)00b54a2735b6724e523a14642acac422$$aCatalano, Calogerina$$b4$$udkfz
000136738 7001_ $$aPardini, Barbara$$b5
000136738 7001_ $$aNaccarati, Alessio$$b6
000136738 7001_ $$aPolakova-Vymetálkova, Veronika$$b7
000136738 7001_ $$00000-0001-8462-6358$$aJiraskova, Katerina$$b8
000136738 7001_ $$aVodickova, Ludmila$$b9
000136738 7001_ $$aVodicka, Pavel$$b10
000136738 7001_ $$aLöffler, Markus W$$b11
000136738 7001_ $$aCourth, Lioba$$b12
000136738 7001_ $$aWehkamp, Jan$$b13
000136738 7001_ $$aDin, Farhat V N$$b14
000136738 7001_ $$aTimofeeva, Maria$$b15
000136738 7001_ $$00000-0001-5955-7389$$aFarrington, Susan M$$b16
000136738 7001_ $$0P:(DE-He78)bbfe0ebad1e3b608bca2b49d4f86bd09$$aJansen, Lina$$b17
000136738 7001_ $$0P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aHemminki, Kari$$b18$$udkfz
000136738 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b19
000136738 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b20
000136738 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b21
000136738 7001_ $$aDunlop, Malcolm G$$b22
000136738 7001_ $$aWeber, Alexander N R$$b23
000136738 7001_ $$0P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aFörsti, Asta$$b24$$eLast author$$udkfz
000136738 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0199350$$gVol. 13, no. 6, p. e0199350 -$$n6$$pe0199350 -$$tPLoS one$$v13$$x1932-6203$$y2018
000136738 909CO $$ooai:inrepo02.dkfz.de:136738$$pVDB
000136738 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)00b54a2735b6724e523a14642acac422$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000136738 9101_ $$0I:(DE-HGF)0$$60000-0001-5955-7389$$aExternal Institute$$b16$$kExtern
000136738 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)bbfe0ebad1e3b608bca2b49d4f86bd09$$aDeutsches Krebsforschungszentrum$$b17$$kDKFZ
000136738 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aDeutsches Krebsforschungszentrum$$b18$$kDKFZ
000136738 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b19$$kDKFZ
000136738 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000136738 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b21$$kDKFZ
000136738 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aDeutsches Krebsforschungszentrum$$b24$$kDKFZ
000136738 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000136738 9141_ $$y2018
000136738 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPLOS ONE : 2015
000136738 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000136738 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000136738 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000136738 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000136738 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000136738 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000136738 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000136738 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000136738 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000136738 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000136738 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000136738 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000136738 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000136738 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000136738 9201_ $$0I:(DE-He78)C050-20160331$$kC050$$lMolekular-Genetische Epidemiologie$$x0
000136738 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x1
000136738 9201_ $$0I:(DE-He78)G110-20160331$$kG110$$lPräventive Onkologie$$x2
000136738 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x3
000136738 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x4
000136738 980__ $$ajournal
000136738 980__ $$aVDB
000136738 980__ $$aI:(DE-He78)C050-20160331
000136738 980__ $$aI:(DE-He78)C070-20160331
000136738 980__ $$aI:(DE-He78)G110-20160331
000136738 980__ $$aI:(DE-He78)C020-20160331
000136738 980__ $$aI:(DE-He78)L101-20160331
000136738 980__ $$aUNRESTRICTED