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@ARTICLE{Kaaks:136740,
      author       = {R. Kaaks$^*$ and R. Turzanski-Fortner$^*$ and A.
                      Hüsing$^*$ and M. Barrdahl$^*$ and M. Hopper and T. S.
                      Johnson$^*$ and A. Tjønneland and L. Hansen and K. Overvad
                      and A. Fournier and M.-C. Boutron-Ruault and M. Kvaskoff and
                      L. Dossus and M. Johansson and H. Boeing and A. Trichopoulou
                      and V. Benetou and C. La Vecchia and S. Sieri and A.
                      Mattiello and D. Palli and R. Tumino and G. Matullo and N.
                      C. Onland-Moret and I. T. Gram and E. Weiderpass and M.-J.
                      Sánchez and C. Navarro Sanchez and E. J. Duell and E.
                      Ardanaz and N. Larranaga and E. Lundin and A. Idahl and K.
                      Jirström and B. Nodin and R. C. Travis and E. Riboli and M.
                      Merritt and D. Aune and K. Terry and D. W. Cramer and K. S.
                      Anderson},
      title        = {{T}umor-associated autoantibodies as early detection
                      markers for ovarian cancer? {A} prospective evaluation.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {3},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01178},
      pages        = {515 - 526},
      year         = {2018},
      abstract     = {Immuno-proteomic screening has identified several
                      tumor-associated autoantibodies (AAb) that may have
                      diagnostic capacity for invasive epithelial ovarian cancer,
                      with AAbs to P53 proteins and cancer-testis antigens (CTAGs)
                      as prominent examples. However, the early detection
                      potential of these AAbs has been insufficiently explored in
                      prospective studies. We performed ELISA measurements of AAbs
                      to CTAG1A, CTAG2, P53 and NUDT11 proteins, for 194 patients
                      with ovarian cancer and 705 matched controls from the
                      European EPIC cohort, using serum samples collected up to 36
                      months prior to diagnosis under usual care. CA125 was
                      measured using electrochemo-luminiscence. Diagnostic
                      discrimination statistics were calculated by strata of
                      lead-time between blood collection and diagnosis. With lead
                      times ≤6 months, ovarian cancer detection sensitivity at
                      0.98 specificity (SE98) varied from 0.19 $[95\%$ CI
                      0.08-0.40] for CTAG1A, CTAG2 and NUDT1 to 0.23 [0.10-0.44]
                      for P53 (0.33 [0.11-0.68] for high-grade serous tumors).
                      However, at longer lead-times, the ability of these AAb
                      markers to distinguish future ovarian cancer cases from
                      controls declined rapidly; at lead times >1 year, SE98
                      estimates were close to zero (all invasive cases, range:
                      0.01-0.11). Compared to CA125 alone, combined logistic
                      regression scores of AAbs and CA125 did not improve
                      detection sensitivity at equal level of specificity. The
                      added value of these selected AAbs as markers for ovarian
                      cancer beyond CA125 for early detection is therefore
                      limited.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29473162},
      pmc          = {pmc:PMC6019150},
      doi          = {10.1002/ijc.31335},
      url          = {https://inrepo02.dkfz.de/record/136740},
}