%0 Journal Article
%A Maalmi, Haifa
%A Walter, Viola
%A Jansen, Lina
%A Boakye, Daniel
%A Schöttker, Ben
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Association between Blood 25-Hydroxyvitamin D Levels and Survival in Colorectal Cancer Patients: An Updated Systematic Review and Meta-Analysis.
%J Nutrients
%V 10
%N 7
%@ 2072-6643
%C Basel
%I MDPI
%M DKFZ-2018-01197
%P E896
%D 2018
%X Previous meta-analyses have shown an improved survival with higher blood 25-hydroxyvitamin D (25(OH)D) concentrations in patients with colorectal cancer (CRC). However, a number of much larger studies have been published since then. We provide an updated meta-analysis to synthesize current evidence. PubMed and Web of Science databases were systematically searched for eligible studies. The dose-response relationships and pooled hazard ratios for overall and CRC-specific survival comparing the highest versus the lowest categories of blood 25(OH)D concentrations were assessed. Subgroup analyses based on study geographic location, year of publication, sample size, length of follow-up time and stage were conducted to explore potential sources of heterogeneity. Overall, 11 original studies with a total of 7718 CRC patients were included. The dose-response meta-analysis showed an improvement in survival outcomes with increasing blood 25(OH)D concentrations. Pooled hazard ratios (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30011816
%2 pmc:PMC6073902
%R 10.3390/nu10070896
%U https://inrepo02.dkfz.de/record/136759