TY  - JOUR
AU  - Maalmi, Haifa
AU  - Walter, Viola
AU  - Jansen, Lina
AU  - Boakye, Daniel
AU  - Schöttker, Ben
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Association between Blood 25-Hydroxyvitamin D Levels and Survival in Colorectal Cancer Patients: An Updated Systematic Review and Meta-Analysis.
JO  - Nutrients
VL  - 10
IS  - 7
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2018-01197
SP  - E896
PY  - 2018
AB  - Previous meta-analyses have shown an improved survival with higher blood 25-hydroxyvitamin D (25(OH)D) concentrations in patients with colorectal cancer (CRC). However, a number of much larger studies have been published since then. We provide an updated meta-analysis to synthesize current evidence. PubMed and Web of Science databases were systematically searched for eligible studies. The dose-response relationships and pooled hazard ratios for overall and CRC-specific survival comparing the highest versus the lowest categories of blood 25(OH)D concentrations were assessed. Subgroup analyses based on study geographic location, year of publication, sample size, length of follow-up time and stage were conducted to explore potential sources of heterogeneity. Overall, 11 original studies with a total of 7718 CRC patients were included. The dose-response meta-analysis showed an improvement in survival outcomes with increasing blood 25(OH)D concentrations. Pooled hazard ratios (95
LB  - PUB:(DE-HGF)16
C6  - pmid:30011816
C2  - pmc:PMC6073902
DO  - DOI:10.3390/nu10070896
UR  - https://inrepo02.dkfz.de/record/136759
ER  -