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@ARTICLE{Maalmi:136759,
      author       = {H. Maalmi$^*$ and V. Walter$^*$ and L. Jansen$^*$ and D.
                      Boakye$^*$ and B. Schöttker$^*$ and M. Hoffmeister$^*$ and
                      H. Brenner$^*$},
      title        = {{A}ssociation between {B}lood 25-{H}ydroxyvitamin {D}
                      {L}evels and {S}urvival in {C}olorectal {C}ancer {P}atients:
                      {A}n {U}pdated {S}ystematic {R}eview and {M}eta-{A}nalysis.},
      journal      = {Nutrients},
      volume       = {10},
      number       = {7},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2018-01197},
      pages        = {E896},
      year         = {2018},
      abstract     = {Previous meta-analyses have shown an improved survival with
                      higher blood 25-hydroxyvitamin D (25(OH)D) concentrations in
                      patients with colorectal cancer (CRC). However, a number of
                      much larger studies have been published since then. We
                      provide an updated meta-analysis to synthesize current
                      evidence. PubMed and Web of Science databases were
                      systematically searched for eligible studies. The
                      dose-response relationships and pooled hazard ratios for
                      overall and CRC-specific survival comparing the highest
                      versus the lowest categories of blood 25(OH)D concentrations
                      were assessed. Subgroup analyses based on study geographic
                      location, year of publication, sample size, length of
                      follow-up time and stage were conducted to explore potential
                      sources of heterogeneity. Overall, 11 original studies with
                      a total of 7718 CRC patients were included. The
                      dose-response meta-analysis showed an improvement in
                      survival outcomes with increasing blood 25(OH)D
                      concentrations. Pooled hazard ratios $(95\%$ confidence
                      intervals) comparing highest versus lowest categories were
                      0.68 (0.55⁻0.85) and 0.67 (0.57⁻0.78) for overall and
                      CRC-specific survival, respectively. Associations were more
                      prominent among studies conducted in Europe, with larger
                      sample sizes, and including stage I⁻IV patients. This
                      updated meta-analysis reveals robust evidence of an
                      association between higher blood 25(OH)D concentrations and
                      better survival in CRC patients. The potential for enhancing
                      prognosis of CRC patients by vitamin D supplementation
                      should be explored by randomized trials.},
      subtyp        = {Review Article},
      cin          = {C070 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30011816},
      pmc          = {pmc:PMC6073902},
      doi          = {10.3390/nu10070896},
      url          = {https://inrepo02.dkfz.de/record/136759},
}