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@ARTICLE{Miller:136766,
      author       = {C. N. Miller and I. Proekt and J. von Moltke and K. L.
                      Wells and A. R. Rajpurkar and H. Wang and K. Rattay$^*$ and
                      I. S. Khan and T. C. Metzger and J. L. Pollack and A. C.
                      Fries and W. W. Lwin and E. J. Wigton and A. V. Parent and
                      B. Kyewski$^*$ and D. J. Erle and K. A. Hogquist and L. M.
                      Steinmetz and R. M. Locksley and M. S. Anderson},
      title        = {{T}hymic tuft cells promote an {IL}-4-enriched medulla and
                      shape thymocyte development.},
      journal      = {Nature},
      volume       = {559},
      number       = {7715},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2018-01204},
      pages        = {627 - 631},
      year         = {2018},
      abstract     = {The thymus is responsible for generating a diverse yet
                      self-tolerant pool of T cells1. Although the thymic medulla
                      consists mostly of developing and mature AIRE+ epithelial
                      cells, recent evidence has suggested that there is far
                      greater heterogeneity among medullary thymic epithelial
                      cells than was previously thought2. Here we describe in
                      detail an epithelial subset that is remarkably similar to
                      peripheral tuft cells that are found at mucosal barriers3.
                      Similar to the periphery, thymic tuft cells express the
                      canonical taste transduction pathway and IL-25. However,
                      they are unique in their spatial association with cornified
                      aggregates, ability to present antigens and expression of a
                      broad diversity of taste receptors. Some thymic tuft cells
                      pass through an Aire-expressing stage and depend on a known
                      AIRE-binding partner, HIPK2, for their development. Notably,
                      the taste chemosensory protein TRPM5 is required for their
                      thymic function through which they support the development
                      and polarization of thymic invariant natural killer T cells
                      and act to establish a medullary microenvironment that is
                      enriched in the type 2 cytokine, IL-4. These findings
                      indicate that there is a compartmentalized medullary
                      environment in which differentiation of a minor and highly
                      specialized epithelial subset has a non-redundant role in
                      shaping thymic function.},
      cin          = {D090},
      ddc          = {500},
      cid          = {I:(DE-He78)D090-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30022164},
      pmc          = {pmc:PMC6062473},
      doi          = {10.1038/s41586-018-0345-2},
      url          = {https://inrepo02.dkfz.de/record/136766},
}