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@ARTICLE{Moscariello:136767,
      author       = {P. Moscariello and D. Y. W. Ng and M. Jansen$^*$ and T.
                      Weil and H. J. Luhmann and J. Hedrich},
      title        = {{B}rain {D}elivery of {M}ultifunctional {D}endrimer
                      {P}rotein {B}ioconjugates.},
      journal      = {Advanced science},
      volume       = {5},
      number       = {5},
      issn         = {2198-3844},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {DKFZ-2018-01205},
      pages        = {1700897},
      year         = {2018},
      abstract     = {Neurological disorders are undoubtedly among the most
                      alarming diseases humans might face. In treatment of
                      neurological disorders, the blood-brain barrier (BBB) is a
                      challenging obstacle preventing drug penetration into the
                      brain. Advances in dendrimer chemistry for central nervous
                      system (CNS) treatments are presented here. A
                      poly(amido)amine (PAMAM) dendrimer bioconjugate with a
                      streptavidin adapter for the attachment of dendrons or any
                      biotinylated drug is constructed. In vitro studies on
                      porcine or murine models and in vivo mouse studies are
                      performed and reveal the permeation of dendronized
                      streptavidin (DSA) into the CNS. The bioconjugate is taken
                      up mainly by the caveolae pathway and transported across the
                      BBB via transcytosis escaping from lysosomes. After
                      transcytosis DSA are delivered to astrocytes and neurons.
                      Furthermore, DSA offer high biocompatibility in vitro and in
                      vivo. In summary, a new strategy for implementing
                      therapeutic PAMAM function as well as drug delivery in
                      neuropathology is presented here.},
      cin          = {A240},
      ddc          = {500},
      cid          = {I:(DE-He78)A240-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29876217},
      pmc          = {pmc:PMC5979778},
      doi          = {10.1002/advs.201700897},
      url          = {https://inrepo02.dkfz.de/record/136767},
}