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000136770 1001_ $$00000-0003-1049-6225$$aNaudin, Sabine$$b0
000136770 245__ $$aLifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study.
000136770 260__ $$aBognor Regis$$bWiley-Liss$$c2018
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000136770 520__ $$aRecent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake.
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000136770 7001_ $$aLi, Kuanrong$$b1
000136770 7001_ $$aJaouen, Tristan$$b2
000136770 7001_ $$aAssi, Nada$$b3
000136770 7001_ $$00000-0002-9083-8960$$aKyrø, Cecilie$$b4
000136770 7001_ $$aTjønneland, Anne$$b5
000136770 7001_ $$aOvervad, Kim$$b6
000136770 7001_ $$aBoutron-Ruault, Marie-Christine$$b7
000136770 7001_ $$aRebours, Vinciane$$b8
000136770 7001_ $$aVédié, Anne-Laure$$b9
000136770 7001_ $$aBoeing, Heiner$$b10
000136770 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b11$$udkfz
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000136770 7001_ $$aBamia, Christina$$b13
000136770 7001_ $$aNaska, Androniki$$b14
000136770 7001_ $$aTrichopoulou, Antonia$$b15
000136770 7001_ $$aBerrino, Franco$$b16
000136770 7001_ $$aTagliabue, Giovanna$$b17
000136770 7001_ $$00000-0002-5558-2437$$aPalli, Domenico$$b18
000136770 7001_ $$aPanico, Salvatore$$b19
000136770 7001_ $$aTumino, Rosario$$b20
000136770 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b21
000136770 7001_ $$aPeeters, Petra H$$b22
000136770 7001_ $$aBueno-de-Mesquita, H B As$$b23
000136770 7001_ $$aWeiderpass, Elisabete$$b24
000136770 7001_ $$aGram, Inger Torhild$$b25
000136770 7001_ $$aSkeie, Guri$$b26
000136770 7001_ $$aChirlaque, Maria-Dolores$$b27
000136770 7001_ $$aRodríguez-Barranco, Miguel$$b28
000136770 7001_ $$aBarricarte, Aurelio$$b29
000136770 7001_ $$aQuirós, Jose Ramón$$b30
000136770 7001_ $$aDorronsoro, Miren$$b31
000136770 7001_ $$aJohansson, Ingegerd$$b32
000136770 7001_ $$aSund, Malin$$b33
000136770 7001_ $$aSternby, Hanna$$b34
000136770 7001_ $$00000-0003-3345-7333$$aBradbury, Kathryn E$$b35
000136770 7001_ $$aWareham, Nick$$b36
000136770 7001_ $$aRiboli, Elio$$b37
000136770 7001_ $$aGunter, Marc$$b38
000136770 7001_ $$aBrennan, Paul$$b39
000136770 7001_ $$00000-0001-5256-0163$$aDuell, Eric J$$b40
000136770 7001_ $$aFerrari, Pietro$$b41
000136770 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.31367$$gVol. 143, no. 4, p. 801 - 812$$n4$$p801 - 812$$tInternational journal of cancer$$v143$$x0020-7136$$y2018
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