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@ARTICLE{Naudin:136770,
      author       = {S. Naudin and K. Li and T. Jaouen and N. Assi and C. Kyrø
                      and A. Tjønneland and K. Overvad and M.-C. Boutron-Ruault
                      and V. Rebours and A.-L. Védié and H. Boeing and R.
                      Kaaks$^*$ and V. Katzke$^*$ and C. Bamia and A. Naska and A.
                      Trichopoulou and F. Berrino and G. Tagliabue and D. Palli
                      and S. Panico and R. Tumino and C. Sacerdote and P. H.
                      Peeters and H. B. A. Bueno-de-Mesquita and E. Weiderpass and
                      I. T. Gram and G. Skeie and M.-D. Chirlaque and M.
                      Rodríguez-Barranco and A. Barricarte and J. R. Quirós and
                      M. Dorronsoro and I. Johansson and M. Sund and H. Sternby
                      and K. E. Bradbury and N. Wareham and E. Riboli and M.
                      Gunter and P. Brennan and E. J. Duell and P. Ferrari},
      title        = {{L}ifetime and baseline alcohol intakes and risk of
                      pancreatic cancer in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition study.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {4},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01208},
      pages        = {801 - 812},
      year         = {2018},
      abstract     = {Recent evidence suggested a weak relationship between
                      alcohol consumption and pancreatic cancer (PC) risk. In our
                      study, the association between lifetime and baseline alcohol
                      intakes and the risk of PC was evaluated, including the type
                      of alcoholic beverages and potential interaction with
                      smoking. Within the European Prospective Investigation into
                      Cancer and Nutrition (EPIC) study, 1,283 incident PC $(57\%$
                      women) were diagnosed from 476,106 cancer-free participants,
                      followed up for 14 years. Amounts of lifetime and baseline
                      alcohol were estimated through lifestyle and dietary
                      questionnaires, respectively. Cox proportional hazard models
                      with age as primary time variable were used to estimate PC
                      hazard ratios (HR) and their $95\%$ confidence interval
                      (CI). Alcohol intake was positively associated with PC risk
                      in men. Associations were mainly driven by extreme alcohol
                      levels, with HRs comparing heavy drinkers (>60 g/day) to the
                      reference category (0.1-4.9 g/day) equal to 1.77 $(95\%$ CI:
                      1.06, 2.95) and 1.63 $(95\%$ CI: 1.16, 2.29) for lifetime
                      and baseline alcohol, respectively. Baseline alcohol intakes
                      from beer (>40 g/day) and spirits/liquors (>10 g/day) showed
                      HRs equal to 1.58 $(95\%$ CI: 1.07, 2.34) and 1.41 $(95\%$
                      CI: 1.03, 1.94), respectively, compared to the reference
                      category (0.1-2.9 g/day). In women, HR estimates did not
                      reach statistically significance. The alcohol and PC risk
                      association was not modified by smoking status. Findings
                      from a large prospective study suggest that baseline and
                      lifetime alcohol intakes were positively associated with PC
                      risk, with more apparent risk estimates for beer and
                      spirits/liquors than wine intake.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29524225},
      doi          = {10.1002/ijc.31367},
      url          = {https://inrepo02.dkfz.de/record/136770},
}