%0 Journal Article
%A Pajtler, Kristian
%A Wen, Ji
%A Sill, Martin
%A Lin, Tong
%A Orisme, Wilda
%A Tang, Bo
%A Hübner, Jens-Martin
%A Ramaswamy, Vijay
%A Jia, Sujuan
%A Dalton, James D
%A Haupfear, Kelly
%A Rogers, Hazel A
%A Punchihewa, Chandanamali
%A Lee, Ryan
%A Easton, John
%A Wu, Gang
%A Ritzmann, Timothy A
%A Chapman, Rebecca
%A Chavez, Lukas
%A Boop, Fredrick A
%A Klimo, Paul
%A Sabin, Noah D
%A Ogg, Robert
%A Mack, Stephen C
%A Freibaum, Brian D
%A Kim, Hong Joo
%A Witt, Hendrik
%A Jones, David
%A Vo, Baohan
%A Gajjar, Amar
%A Pounds, Stan
%A Onar-Thomas, Arzu
%A Roussel, Martine F
%A Zhang, Jinghui
%A Taylor, J Paul
%A Merchant, Thomas E
%A Grundy, Richard
%A Tatevossian, Ruth G
%A Taylor, Michael D
%A Pfister, Stefan M
%A Korshunov, Andrey
%A Kool, Marcel
%A Ellison, David W
%T Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
%J Acta neuropathologica
%V 136
%N 2
%@ 1432-0533
%C Berlin
%I Springer
%M DKFZ-2018-01220
%P 211 - 226
%D 2018
%X Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further molecular heterogeneity among 675 PFA ependymomas. Two major subgroups, PFA-1 and PFA-2, and nine minor subtypes were discovered. Transcriptome profiling suggested a distinct histogenesis for PFA-1 and PFA-2, but their clinical parameters were similar. In contrast, PFA subtypes differed with respect to age at diagnosis, gender ratio, outcome, and frequencies of genetic alterations. One subtype, PFA-1c, was enriched for 1q gain and had a relatively poor outcome, while patients with PFA-2c ependymomas showed an overall survival at 5 years of > 90
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29909548
%2 pmc:PMC6105278
%R 10.1007/s00401-018-1877-0
%U https://inrepo02.dkfz.de/record/136782