TY  - JOUR
AU  - Pajtler, Kristian
AU  - Wen, Ji
AU  - Sill, Martin
AU  - Lin, Tong
AU  - Orisme, Wilda
AU  - Tang, Bo
AU  - Hübner, Jens-Martin
AU  - Ramaswamy, Vijay
AU  - Jia, Sujuan
AU  - Dalton, James D
AU  - Haupfear, Kelly
AU  - Rogers, Hazel A
AU  - Punchihewa, Chandanamali
AU  - Lee, Ryan
AU  - Easton, John
AU  - Wu, Gang
AU  - Ritzmann, Timothy A
AU  - Chapman, Rebecca
AU  - Chavez, Lukas
AU  - Boop, Fredrick A
AU  - Klimo, Paul
AU  - Sabin, Noah D
AU  - Ogg, Robert
AU  - Mack, Stephen C
AU  - Freibaum, Brian D
AU  - Kim, Hong Joo
AU  - Witt, Hendrik
AU  - Jones, David
AU  - Vo, Baohan
AU  - Gajjar, Amar
AU  - Pounds, Stan
AU  - Onar-Thomas, Arzu
AU  - Roussel, Martine F
AU  - Zhang, Jinghui
AU  - Taylor, J Paul
AU  - Merchant, Thomas E
AU  - Grundy, Richard
AU  - Tatevossian, Ruth G
AU  - Taylor, Michael D
AU  - Pfister, Stefan M
AU  - Korshunov, Andrey
AU  - Kool, Marcel
AU  - Ellison, David W
TI  - Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
JO  - Acta neuropathologica
VL  - 136
IS  - 2
SN  - 1432-0533
CY  - Berlin
PB  - Springer
M1  - DKFZ-2018-01220
SP  - 211 - 226
PY  - 2018
AB  - Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further molecular heterogeneity among 675 PFA ependymomas. Two major subgroups, PFA-1 and PFA-2, and nine minor subtypes were discovered. Transcriptome profiling suggested a distinct histogenesis for PFA-1 and PFA-2, but their clinical parameters were similar. In contrast, PFA subtypes differed with respect to age at diagnosis, gender ratio, outcome, and frequencies of genetic alterations. One subtype, PFA-1c, was enriched for 1q gain and had a relatively poor outcome, while patients with PFA-2c ependymomas showed an overall survival at 5 years of > 90
LB  - PUB:(DE-HGF)16
C6  - pmid:29909548
C2  - pmc:PMC6105278
DO  - DOI:10.1007/s00401-018-1877-0
UR  - https://inrepo02.dkfz.de/record/136782
ER  -