%0 Journal Article
%A Quintana Pacheco, Daniel Antonio
%A Sookthai, Disorn
%A Graf, Mirja
%A Schübel, Ruth
%A Johnson, Theron Scot
%A Katzke, Verena
%A Kaaks, Rudolf
%A Kühn, Tilman
%T Iron status in relation to cancer risk and mortality: Findings from a population-based prospective study.
%J International journal of cancer
%V 143
%N 3
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2018-01225
%P 561 - 569
%D 2018
%X While experimental evidence suggests potential carcinogenic effects of increased iron load, there is a lack of data on iron status and cancer risk from epidemiological studies. Here, we evaluated prediagnostic serum concentrations of ferritin, iron and transferrin as well as transferrin saturation (TSAT) in relation to cancer risk and mortality in a prospective study by multivariable Cox regression analyses. A case-cohort sample of the population-based EPIC-Heidelberg Study including a random subcohort (n = 2738) and incident cases of breast cancer (n = 627), prostate cancer (n = 554), lung cancer (n = 195), colorectal cancer (n = 256) and cancer death (n = 759) was used. Ferritin levels were inversely associated with breast cancer risk in the multivariable Cox regression model, with a hazard ratio (HR) of 0.67 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29574909
%R 10.1002/ijc.31384
%U https://inrepo02.dkfz.de/record/136787