TY  - JOUR
AU  - Quintana Pacheco, Daniel Antonio
AU  - Sookthai, Disorn
AU  - Graf, Mirja
AU  - Schübel, Ruth
AU  - Johnson, Theron Scot
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Iron status in relation to cancer risk and mortality: Findings from a population-based prospective study.
JO  - International journal of cancer
VL  - 143
IS  - 3
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2018-01225
SP  - 561 - 569
PY  - 2018
AB  - While experimental evidence suggests potential carcinogenic effects of increased iron load, there is a lack of data on iron status and cancer risk from epidemiological studies. Here, we evaluated prediagnostic serum concentrations of ferritin, iron and transferrin as well as transferrin saturation (TSAT) in relation to cancer risk and mortality in a prospective study by multivariable Cox regression analyses. A case-cohort sample of the population-based EPIC-Heidelberg Study including a random subcohort (n = 2738) and incident cases of breast cancer (n = 627), prostate cancer (n = 554), lung cancer (n = 195), colorectal cancer (n = 256) and cancer death (n = 759) was used. Ferritin levels were inversely associated with breast cancer risk in the multivariable Cox regression model, with a hazard ratio (HR) of 0.67 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:29574909
DO  - DOI:10.1002/ijc.31384
UR  - https://inrepo02.dkfz.de/record/136787
ER  -