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@ARTICLE{QuintanaPacheco:136787,
      author       = {D. A. Quintana Pacheco$^*$ and D. Sookthai$^*$ and M.
                      Graf$^*$ and R. Schübel$^*$ and T. S. Johnson$^*$ and V.
                      Katzke$^*$ and R. Kaaks$^*$ and T. Kühn$^*$},
      title        = {{I}ron status in relation to cancer risk and mortality:
                      {F}indings from a population-based prospective study.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {3},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01225},
      pages        = {561 - 569},
      year         = {2018},
      abstract     = {While experimental evidence suggests potential carcinogenic
                      effects of increased iron load, there is a lack of data on
                      iron status and cancer risk from epidemiological studies.
                      Here, we evaluated prediagnostic serum concentrations of
                      ferritin, iron and transferrin as well as transferrin
                      saturation (TSAT) in relation to cancer risk and mortality
                      in a prospective study by multivariable Cox regression
                      analyses. A case-cohort sample of the population-based
                      EPIC-Heidelberg Study including a random subcohort
                      (n = 2738) and incident cases of breast cancer
                      (n = 627), prostate cancer (n = 554), lung cancer
                      (n = 195), colorectal cancer (n = 256) and cancer
                      death (n = 759) was used. Ferritin levels were inversely
                      associated with breast cancer risk in the multivariable Cox
                      regression model, with a hazard ratio (HR) of 0.67 $[95\%$
                      confidence interval: 0.49, 0.92] for women in the highest
                      quartile compared to those in the lowest quartile. Neither
                      ferritin nor the other markers of iron status were
                      significantly associated with colorectal, prostate or lung
                      cancer risk. An inverse association was observed between
                      ferritin and total cancer mortality (HR: 0.70 [0.53, 0.92]).
                      There were no significant overall associations between serum
                      iron, transferrin or TSAT and cancer mortality. The present
                      findings do not support the notion of increased iron load
                      constituting a cancer risk factor in the general population.
                      By contrast, our analyses revealed inverse associations
                      between ferritin levels and breast cancer risk as well as
                      cancer mortality.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29574909},
      doi          = {10.1002/ijc.31384},
      url          = {https://inrepo02.dkfz.de/record/136787},
}