%0 Journal Article
%A Reinhardt, Annekathrin
%A Stichel, Damian
%A Schrimpf, Daniel
%A Sahm, Felix
%A Korshunov, Andrey
%A Reuss, David E
%A Koelsche, Christian
%A Huang, Kristin
%A Wefers, Annika K
%A Hovestadt, Volker
%A Sill, Martin
%A Gramatzki, Dorothee
%A Felsberg, Joerg
%A Reifenberger, Guido
%A Koch, Arend
%A Thomale, Ulrich-W
%A Becker, Albert
%A Hans, Volkmar H
%A Prinz, Marco
%A Staszewski, Ori
%A Acker, Till
%A Dohmen, Hildegard
%A Hartmann, Christian
%A Mueller, Wolf
%A Tuffaha, Muin S A
%A Paulus, Werner
%A Heß, Katharina
%A Brokinkel, Benjamin
%A Schittenhelm, Jens
%A Monoranu, Camelia-Maria
%A Kessler, Almuth Friederike
%A Loehr, Mario
%A Buslei, Rolf
%A Deckert, Martina
%A Mawrin, Christian
%A Kohlhof, Patricia
%A Hewer, Ekkehard
%A Olar, Adriana
%A Rodriguez, Fausto J
%A Giannini, Caterina
%A NageswaraRao, Amulya A
%A Tabori, Uri
%A Nunes, Nuno Miguel
%A Weller, Michael
%A Pohl, Ute
%A Jaunmuktane, Zane
%A Brandner, Sebastian
%A Unterberg, Andreas
%A Hänggi, Daniel
%A Platten, Michael
%A Pfister, Stefan
%A Wick, Wolfgang
%A Herold-Mende, Christel
%A Jones, David
%A von Deimling, Andreas
%A Capper, David
%T Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.
%J Acta neuropathologica
%V 136
%N 2
%@ 1432-0533
%C Berlin
%I Springer
%M DKFZ-2018-01227
%P 273 - 291
%D 2018
%X Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly microvascular proliferation and palisading necrosis) have often been designated anaplastic pilocytic astrocytomas. The status of these tumors as a separate entity has not yet been conclusively demonstrated and molecular features have only been partially characterized. We performed DNA methylation profiling of 102 histologically defined anaplastic pilocytic astrocytomas. T-distributed stochastic neighbor-embedding (t-SNE) and hierarchical clustering analysis of these 102 cases against 158 reference cases from 12 glioma reference classes revealed that a subset of 83 of these tumors share a common DNA methylation profile that is distinct from the reference classes. These 83 tumors were thus denominated DNA methylation class anaplastic astrocytoma with piloid features (MC AAP). The 19 remaining tumors were distributed amongst the reference classes, with additional testing confirming the molecular diagnosis in most cases. Median age of patients with MC AAP was 41.5 years. The most frequent localization was the posterior fossa (74
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29564591
%R 10.1007/s00401-018-1837-8
%U https://inrepo02.dkfz.de/record/136789