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@ARTICLE{Tikk:136820,
      author       = {K. Tikk$^*$ and K. Weigl$^*$ and M. Hoffmeister$^*$ and S.
                      Igel and M. Schwab and J. Hampe and S. J. Klug and U.
                      Mansmann and F. Kolligs and H. Brenner$^*$},
      title        = {{S}tudy protocol of the {R}a{PS} study: novel risk adapted
                      prevention strategies for people with a family history of
                      colorectal cancer.},
      journal      = {BMC cancer},
      volume       = {18},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2018-01258},
      pages        = {720},
      year         = {2018},
      abstract     = {People aged 40-60 years with a family history (FH) of
                      colorectal cancer (CRC) in 1st degree relatives (FDRs) have
                      a 2- to 4-fold increased risk of CRC compared to the average
                      risk population. Therefore, experts recommend starting CRC
                      screening earlier for this high-risk group. However,
                      information on prevalence of relevant colonoscopic findings
                      in this group is sparse, and no risk adapted screening
                      offers are implemented in the German health care system. For
                      example, screening colonoscopy is uniformly offered from age
                      55 on, regardless of family history. Thus, we initiated a
                      multicenter epidemiological study - the RaPS study (Risk
                      adapted prevention strategies for colorectal cancer) - with
                      the following aims: to determine the prevalence of having a
                      FH of CRC in FDR in the German population aged 40-54 years;
                      to investigate the prevalence of colorectal neoplasms among
                      people with a FDR; and to develop risk-adapted prevention
                      strategies for this high-risk group based on the collected
                      information.A random sample of 160.000 persons from the
                      general population aged 40-54 years from the catchment
                      areas of three study centers in Germany (Dresden, Munich and
                      Stuttgart) are contacted to assess FH of CRC by an
                      online-questionnaire. Those with a FH of CRC in FDRs are
                      invited to the study centers for individual consultation
                      regarding CRC prevention. Participants are asked to donate
                      blood and stool samples and medical records of colonoscopies
                      will be obtained. Prevalence of CRC and its precursors will
                      be evaluated. Furthermore, genetic, epigenetic and proteomic
                      biomarkers in blood and microbiomic biomarkers in stool will
                      be investigated. Risk markers and their eligibility for risk
                      adapted screening offers will be examined.This study will
                      provide data on the prevalence of colorectal neoplasms among
                      persons with a FH of CRC in the age group 40-54 years,
                      which will enable us to derive evidence based screening
                      strategies for this high-risk group.This trial was
                      registered retrospectively in the German Clinical Trials
                      Register (DRKS) on 29th of December 2016: German Clinical
                      Trials Register DRKS-ID: DRKS00007842 .},
      cin          = {C070 / L101 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)G110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29976178},
      pmc          = {pmc:PMC6034214},
      doi          = {10.1186/s12885-018-4646-5},
      url          = {https://inrepo02.dkfz.de/record/136820},
}