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@ARTICLE{Titz:136821,
      author       = {C. Titz$^*$ and S. Hummler and M. Schmidt$^*$ and M. Thomas
                      and M. Steins and J. Wiskemann$^*$},
      title        = {{E}xercise behavior and physical fitness in patients with
                      advanced lung cancer.},
      journal      = {Supportive care in cancer},
      volume       = {26},
      number       = {8},
      issn         = {1433-7339},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2018-01259},
      pages        = {2725 - 2736},
      year         = {2018},
      abstract     = {The aim of this work was to evaluate exercise behavior and
                      physical fitness of advanced lung cancer patients shortly
                      after primary diagnosis.Between November 2013 and December
                      2016, advanced lung cancer patients (n = 227, mean age
                      62.2 years) were enrolled shortly after diagnosis and 211
                      patients were tested for endurance capacity (six-minute walk
                      test) and strength performance (maximum voluntary isometric
                      contraction of upper and lower extremities). Current and
                      previous exercise and walking behavior were assessed using a
                      self-reported questionnaire regarding type, frequency,
                      intensity, and duration. Paired Student's t tests were used
                      to compare physical fitness to reference data. The relation
                      of potential determinants with physical fitness was assessed
                      using linear regression analysis.Exercise behavior was
                      superior in the year before diagnosis compared to the time
                      of study enrollment. Patients reduced frequency, intensity,
                      and duration of sports/exercise after their lung cancer
                      diagnosis. We observed significantly lower endurance
                      capacity (p < .01) and strength performance in lower
                      extremities (p < .01) in male and female patients
                      compared to age and sex-matched reference data. We found
                      significant correlations of previous exercise and walking
                      behavior with physical fitness shortly after diagnosis in
                      patients with advanced lung cancer.Patients with advanced
                      lung cancer showed impaired physical fitness regarding
                      endurance and strength capacity. The strong decline in
                      participation of sports/exercise shortly after diagnosis
                      supports early implementation of physical exercise during
                      anti-cancer treatment.ClinicalTrials.gov NCT02055508.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29480444},
      doi          = {10.1007/s00520-018-4105-5},
      url          = {https://inrepo02.dkfz.de/record/136821},
}