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000136825 1001_ $$avan Roekel, Eline H$$b0
000136825 245__ $$aCirculating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort.
000136825 260__ $$aBasel$$bMDPI$$c2018
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000136825 520__ $$aIdentifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.
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000136825 7001_ $$aTrijsburg, Laura$$b1
000136825 7001_ $$aAssi, Nada$$b2
000136825 7001_ $$00000-0002-4847-5780$$aCarayol, Marion$$b3
000136825 7001_ $$aAchaintre, David$$b4
000136825 7001_ $$aMurphy, Neil$$b5
000136825 7001_ $$aRinaldi, Sabina$$b6
000136825 7001_ $$00000-0002-7733-8750$$aSchmidt, Julie A$$b7
000136825 7001_ $$aStepien, Magdalena$$b8
000136825 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b9$$udkfz
000136825 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b10$$udkfz
000136825 7001_ $$aBoeing, Heiner$$b11
000136825 7001_ $$00000-0002-3312-4259$$aIqbal, Khalid$$b12
000136825 7001_ $$aPalli, Domenico$$b13
000136825 7001_ $$aKrogh, Vittorio$$b14
000136825 7001_ $$aTumino, Rosario$$b15
000136825 7001_ $$00000-0001-8749-9737$$aRicceri, Fulvio$$b16
000136825 7001_ $$aPanico, Salvatore$$b17
000136825 7001_ $$aPeeters, Petra H$$b18
000136825 7001_ $$aBueno-de-Mesquita, Bas$$b19
000136825 7001_ $$aArdanaz, Eva$$b20
000136825 7001_ $$aLujan-Barroso, Leila$$b21
000136825 7001_ $$aQuirós, J Ramón$$b22
000136825 7001_ $$00000-0002-9637-3869$$aHuerta, José M$$b23
000136825 7001_ $$aMolina-Portillo, Elena$$b24
000136825 7001_ $$aDorronsoro, Miren$$b25
000136825 7001_ $$00000-0002-8452-8472$$aTsilidis, Konstantinos K$$b26
000136825 7001_ $$aRiboli, Elio$$b27
000136825 7001_ $$aRostgaard-Hansen, Agnetha Linn$$b28
000136825 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b29
000136825 7001_ $$aOvervad, Kim$$b30
000136825 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b31
000136825 7001_ $$aBoutron-Ruault, Marie-Christine$$b32
000136825 7001_ $$aSeveri, Gianluca$$b33
000136825 7001_ $$aTrichopoulou, Antonia$$b34
000136825 7001_ $$aKarakatsani, Anna$$b35
000136825 7001_ $$aKotanidou, Anastasia$$b36
000136825 7001_ $$00000-0002-5800-8975$$aHåkansson, Anders$$b37
000136825 7001_ $$aMalm, Johan$$b38
000136825 7001_ $$00000-0003-1695-4768$$aWeijenberg, Matty P$$b39
000136825 7001_ $$aGunter, Marc J$$b40
000136825 7001_ $$aJenab, Mazda$$b41
000136825 7001_ $$aJohansson, Mattias$$b42
000136825 7001_ $$aTravis, Ruth C$$b43
000136825 7001_ $$aScalbert, Augustin$$b44
000136825 7001_ $$aFerrari, Pietro$$b45
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