TY  - JOUR
AU  - Weigl, Korbinian
AU  - Thomsen, Hauke
AU  - Balavarca, Yesilda
AU  - Hellwege, Jacklyn N
AU  - Shrubsole, Martha J
AU  - Brenner, Hermann
TI  - Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population.
JO  - Gastroenterology
VL  - 155
IS  - 1
SN  - 0016-5085
CY  - Stanford, Calif.
PB  - HighWire Press
M1  - DKFZ-2018-01269
SP  - 88 - 98.e10
PY  - 2018
AB  - The presence of specific single nucleotide polymorphisms (SNPs) can be used to calculate an individual's risk for colorectal cancer (CRC), called a genetic risk score (GRS). We investigated whether GRS can identify individuals with clinically relevant neoplasms in a screening colonoscopy population.We derived a GRS based on 48 SNPs associated with CRC, identified in a comprehensive literature search. We obtained genetic data from 1043 participants (50-79 years old) in a screening colonoscopy study in Germany, recruited from 2005 through 2013 (294 with advanced neoplasms, 249 with non-advanced adenoma (NAAs), and 500 without neoplasms). Each participant was assigned a GRS by aggregating their risk alleles (0, 1, or 2). Risk of advanced neoplasms and NAA according to GRS was calculated by multiple logistic regression. Risk advancement periods were calculated. We replicated our findings using data from a subset of the Tennessee Colorectal Polyp Study.An increased GRS was associated with higher prevalence of advanced neoplasms, but not NAAs. Participants in the middle and upper tertiles of GRS had a 2.2-fold and 2.7-fold increase in risk, respectively, of advanced neoplasms compared to those in the lower tertile. Adjusted odds ratios (ORs) were 1.09 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:29574091
C2  - pmc:PMC6035076
DO  - DOI:10.1053/j.gastro.2018.03.030
UR  - https://inrepo02.dkfz.de/record/136831
ER  -