guest ::
| Home > Publications database > Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. > print |
| Home > Publications database > Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. > print |
| 001 | 136849 | ||
| 005 | 20240229105103.0 | ||
| 024 | 7 | _ | |a 10.1038/s41591-018-0095-6 |2 doi |
| 024 | 7 | _ | |a pmid:29988124 |2 pmid |
| 024 | 7 | _ | |a 1078-8956 |2 ISSN |
| 024 | 7 | _ | |a 1546-170X |2 ISSN |
| 024 | 7 | _ | |a altmetric:44730680 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-01287 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bunse, Lukas |0 P:(DE-He78)e579130c57e8c686ed1c2dedfa595985 |b 0 |e First author |
| 245 | _ | _ | |a Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. |
| 260 | _ | _ | |a New York, NY |c 2018 |b Nature America Inc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1659534345_29254 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: tumor cell-derived R-2-HG is taken up by T cells where it induces a perturbation of nuclear factor of activated T cells transcriptional activity and polyamine biosynthesis, resulting in suppression of T cell activity. IDH1-mutant gliomas display reduced T cell abundance and altered calcium signaling. Antitumor immunity to experimental syngeneic IDH1-mutant tumors induced by IDH1-specific vaccine or checkpoint inhibition is improved by inhibition of the neomorphic enzymatic function of mutant IDH1. These data attribute a novel, non-tumor cell-autonomous role to an oncometabolite in shaping the tumor immune microenvironment. |
| 536 | _ | _ | |a 317 - Translational cancer research (POF3-317) |0 G:(DE-HGF)POF3-317 |c POF3-317 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Pusch, Stefan |0 P:(DE-He78)f2efee17b6ca2f790176a2c036912536 |b 1 |e First author |
| 700 | 1 | _ | |a Bunse, Theresa |0 P:(DE-He78)e681100c540b628a2bdbd48772b4fb50 |b 2 |e First author |
| 700 | 1 | _ | |a Sahm, Felix |0 P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88 |b 3 |
| 700 | 1 | _ | |a Sanghvi, Khwab |0 P:(DE-He78)ca9f3aa4fcee93af10f7e792516e7193 |b 4 |
| 700 | 1 | _ | |a Friedrich, Mirco |0 P:(DE-He78)1cab354af0aff62f1b8d569477b4be4c |b 5 |
| 700 | 1 | _ | |a Alansary, Dalia |b 6 |
| 700 | 1 | _ | |a Sonner, Jana |0 P:(DE-He78)1f1efec9a95d1778031cb6f0b19ba58b |b 7 |
| 700 | 1 | _ | |a Green, Edward |0 P:(DE-He78)9b97ca569bcb00dfda69382bc7261700 |b 8 |
| 700 | 1 | _ | |a Deumelandt, Katrin |0 P:(DE-He78)c1a5de00fb2617c5c43d8f30f6e0cd2b |b 9 |
| 700 | 1 | _ | |a Kilian, Michael |0 P:(DE-He78)bed62b0b74cf1048663fbefeb4b5d7bc |b 10 |
| 700 | 1 | _ | |a Neftel, Cyril |b 11 |
| 700 | 1 | _ | |a Uhlig, Stefanie |b 12 |
| 700 | 1 | _ | |a Kessler, Tobias |0 P:(DE-He78)5c2c9cbe6ce72553684d82d94aebdadd |b 13 |
| 700 | 1 | _ | |a von Landenberg, Anna |0 P:(DE-He78)e33cce63a8732306894f1135dca8e119 |b 14 |
| 700 | 1 | _ | |a Berghoff, Anna Sophie |0 P:(DE-He78)5b87d282e810365cc9599b1384318145 |b 15 |
| 700 | 1 | _ | |a Marsh, Kelly |b 16 |
| 700 | 1 | _ | |a Steadman, Mya |b 17 |
| 700 | 1 | _ | |a Zhu, Dongwei |b 18 |
| 700 | 1 | _ | |a Nicolay, Brandon |b 19 |
| 700 | 1 | _ | |a Wiestler, Benedikt |b 20 |
| 700 | 1 | _ | |a Breckwoldt, Michael |0 P:(DE-He78)5ba5b48bd126214d9cb66291fa4ae303 |b 21 |
| 700 | 1 | _ | |a Al-Ali, Ruslan |b 22 |
| 700 | 1 | _ | |a Karcher-Bausch, Simone |0 P:(DE-He78)c9818cef5adc6714cbfeaabbb69d582b |b 23 |
| 700 | 1 | _ | |a Bozza, Matthias |0 P:(DE-He78)3391c5ad790ea5359189d11f073fb103 |b 24 |
| 700 | 1 | _ | |a Oezen, Iris |0 P:(DE-He78)19ad2213f94e3900fa9a1b02f36b965a |b 25 |
| 700 | 1 | _ | |a Kramer, Magdalena |0 P:(DE-He78)4264d8c0f0ad49ff43e0c97a1224d02b |b 26 |
| 700 | 1 | _ | |a Meyer, Jochen |0 P:(DE-He78)b6273c0ba3ae37a4d3d1c6b084797f2e |b 27 |
| 700 | 1 | _ | |a Habel, Antje |0 P:(DE-He78)e1415e1a2d46648d49fa06d0c58b90df |b 28 |
| 700 | 1 | _ | |a Eisel, Jessica |0 P:(DE-He78)e64e97dc855086214ab44e4290f396cd |b 29 |
| 700 | 1 | _ | |a Poschet, Gernot |b 30 |
| 700 | 1 | _ | |a Weller, Michael |b 31 |
| 700 | 1 | _ | |a Preusser, Matthias |b 32 |
| 700 | 1 | _ | |a Nadji-Ohl, Minou |b 33 |
| 700 | 1 | _ | |a Thon, Niklas |b 34 |
| 700 | 1 | _ | |a Burger, Michael C |0 P:(DE-HGF)0 |b 35 |
| 700 | 1 | _ | |a Harter, Patrick |0 P:(DE-He78)b15b56a6ed37417d476470c60c0140ff |b 36 |
| 700 | 1 | _ | |a Ratliff, Miriam |0 P:(DE-HGF)0 |b 37 |
| 700 | 1 | _ | |a Harbottle, Richard |0 P:(DE-He78)15dff5647002b4dcfe892b251cd14b62 |b 38 |
| 700 | 1 | _ | |a Benner, Axel |0 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |b 39 |
| 700 | 1 | _ | |a Schrimpf, Daniel |0 P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc |b 40 |
| 700 | 1 | _ | |a Okun, Jürgen |b 41 |
| 700 | 1 | _ | |a Herold-Mende, Christel |b 42 |
| 700 | 1 | _ | |a Turcan, Sevin |b 43 |
| 700 | 1 | _ | |a Kaulfuss, Stefan |b 44 |
| 700 | 1 | _ | |a Hess-Stumpp, Holger |b 45 |
| 700 | 1 | _ | |a Bieback, Karen |b 46 |
| 700 | 1 | _ | |a Cahill, Daniel P |b 47 |
| 700 | 1 | _ | |a Plate, Karl H |0 P:(DE-HGF)0 |b 48 |
| 700 | 1 | _ | |a Hänggi, Daniel |b 49 |
| 700 | 1 | _ | |a Dorsch, Marion |b 50 |
| 700 | 1 | _ | |a Suvà, Mario L |0 0000-0001-9898-5351 |b 51 |
| 700 | 1 | _ | |a Niemeyer, Barbara A |b 52 |
| 700 | 1 | _ | |a von Deimling, Andreas |0 P:(DE-He78)a8a10626a848d31e70cfd96a133cc144 |b 53 |
| 700 | 1 | _ | |a Wick, Wolfgang |0 P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee |b 54 |
| 700 | 1 | _ | |a Platten, Michael |0 P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5 |b 55 |e Last author |
| 773 | _ | _ | |a 10.1038/s41591-018-0095-6 |g Vol. 24, no. 8, p. 1192 - 1203 |0 PERI:(DE-600)1484517-9 |n 8 |p 1192 - 1203 |t Nature medicine |v 24 |y 2018 |x 1546-170X |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:136849 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)e579130c57e8c686ed1c2dedfa595985 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-He78)f2efee17b6ca2f790176a2c036912536 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)e681100c540b628a2bdbd48772b4fb50 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)ca9f3aa4fcee93af10f7e792516e7193 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)1cab354af0aff62f1b8d569477b4be4c |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 7 |6 P:(DE-He78)1f1efec9a95d1778031cb6f0b19ba58b |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-He78)9b97ca569bcb00dfda69382bc7261700 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)c1a5de00fb2617c5c43d8f30f6e0cd2b |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 10 |6 P:(DE-He78)bed62b0b74cf1048663fbefeb4b5d7bc |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 13 |6 P:(DE-He78)5c2c9cbe6ce72553684d82d94aebdadd |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)e33cce63a8732306894f1135dca8e119 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 15 |6 P:(DE-He78)5b87d282e810365cc9599b1384318145 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 21 |6 P:(DE-He78)5ba5b48bd126214d9cb66291fa4ae303 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 23 |6 P:(DE-He78)c9818cef5adc6714cbfeaabbb69d582b |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 24 |6 P:(DE-He78)3391c5ad790ea5359189d11f073fb103 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 25 |6 P:(DE-He78)19ad2213f94e3900fa9a1b02f36b965a |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 26 |6 P:(DE-He78)4264d8c0f0ad49ff43e0c97a1224d02b |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 27 |6 P:(DE-He78)b6273c0ba3ae37a4d3d1c6b084797f2e |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 28 |6 P:(DE-He78)e1415e1a2d46648d49fa06d0c58b90df |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 29 |6 P:(DE-He78)e64e97dc855086214ab44e4290f396cd |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 35 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 36 |6 P:(DE-He78)b15b56a6ed37417d476470c60c0140ff |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 37 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 38 |6 P:(DE-He78)15dff5647002b4dcfe892b251cd14b62 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 39 |6 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 40 |6 P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 48 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 53 |6 P:(DE-He78)a8a10626a848d31e70cfd96a133cc144 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 54 |6 P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 55 |6 P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-317 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Translational cancer research |x 0 |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT MED : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 30 |0 StatID:(DE-HGF)9930 |2 StatID |b NAT MED : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)G160-20160331 |k G160 |l Neuroimmunologie und Hirntumorimmunologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)L101-20160331 |k L101 |l DKTK Heidelberg |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)G380-20160331 |k G380 |l KKE Neuropathologie |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)F160-20160331 |k F160 |l F160 DNA-Vektoren |x 3 |
| 920 | 1 | _ | |0 I:(DE-He78)L501-20160331 |k L501 |l DKTK Frankfurt |x 4 |
| 920 | 1 | _ | |0 I:(DE-He78)C060-20160331 |k C060 |l C060 Biostatistik |x 5 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)G160-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L101-20160331 |
| 980 | _ | _ | |a I:(DE-He78)G380-20160331 |
| 980 | _ | _ | |a I:(DE-He78)F160-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L501-20160331 |
| 980 | _ | _ | |a I:(DE-He78)C060-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|