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@ARTICLE{Gillmann:136861,
      author       = {C. Gillmann and A. J. Lomax and D. C. Weber and O.
                      Jäkel$^*$ and C. Karger$^*$},
      title        = {{D}ose-response curves for {MRI}-detected radiation-induced
                      temporal lobe reactions in patients after proton and carbon
                      ion therapy: {D}oes the same {RBE}-weighted dose lead to the
                      same biological effect?},
      journal      = {Radiotherapy and oncology},
      volume       = {128},
      number       = {1},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-01299},
      pages        = {109 - 114},
      year         = {2018},
      abstract     = {To derive the dose-response curve for temporal lobe
                      reactions (TLRs) after proton therapy and to compare the
                      resulting relative biological effectiveness (RBE)-weighted
                      tolerance doses based on an RBE of 1.1 with published values
                      for carbon ions, which were calculated by the two versions
                      of the local effect model (LEM I or IV).62 patients treated
                      with protons for skull base tumors were analyzed for TLRs
                      using magnetic resonance imaging. Within the mean follow-up
                      time of 38 months, TLRs were observed in six patients.
                      Dose-response curves based on the RBE-weighted maximum dose,
                      excluding the 1 cm3-volume with the highest dose, were
                      derived and compared to previously published dose-response
                      curves for carbon ions, which were obtained using LEM I or
                      IV, respectively.The dose-response curves for protons and
                      LEM I were found to be almost identical while the curve of
                      LEM IV was shifted toward higher doses. The resulting
                      tolerance doses at the $5\%$ effect level were 68.2+2.7-5.6,
                      68.6+3.0-3.9 and 78.3+3.8-5.0 Gy (RBE), respectively.The
                      RBE-weighted dose prescription for protons leads to the same
                      RBE-weighted dose-response curve for TLR as the one for LEM
                      I-based carbon ions, while LEM IV predicts clinically
                      significant higher tolerance doses.},
      cin          = {E040},
      ddc          = {610},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29459152},
      doi          = {10.1016/j.radonc.2018.01.018},
      url          = {https://inrepo02.dkfz.de/record/136861},
}