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| 024 | 7 | _ | |a 10.1016/j.radonc.2018.01.018 |2 doi |
| 024 | 7 | _ | |a pmid:29459152 |2 pmid |
| 024 | 7 | _ | |a 0167-8140 |2 ISSN |
| 024 | 7 | _ | |a 1879-0887 |2 ISSN |
| 024 | 7 | _ | |a altmetric:33342534 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-01299 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Gillmann, Clarissa |b 0 |
| 245 | _ | _ | |a Dose-response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect? |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2018 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1536224763_3642 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a To derive the dose-response curve for temporal lobe reactions (TLRs) after proton therapy and to compare the resulting relative biological effectiveness (RBE)-weighted tolerance doses based on an RBE of 1.1 with published values for carbon ions, which were calculated by the two versions of the local effect model (LEM I or IV).62 patients treated with protons for skull base tumors were analyzed for TLRs using magnetic resonance imaging. Within the mean follow-up time of 38 months, TLRs were observed in six patients. Dose-response curves based on the RBE-weighted maximum dose, excluding the 1 cm3-volume with the highest dose, were derived and compared to previously published dose-response curves for carbon ions, which were obtained using LEM I or IV, respectively.The dose-response curves for protons and LEM I were found to be almost identical while the curve of LEM IV was shifted toward higher doses. The resulting tolerance doses at the 5% effect level were 68.2+2.7-5.6, 68.6+3.0-3.9 and 78.3+3.8-5.0 Gy (RBE), respectively.The RBE-weighted dose prescription for protons leads to the same RBE-weighted dose-response curve for TLR as the one for LEM I-based carbon ions, while LEM IV predicts clinically significant higher tolerance doses. |
| 536 | _ | _ | |a 315 - Imaging and radiooncology (POF3-315) |0 G:(DE-HGF)POF3-315 |c POF3-315 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Lomax, Antony J |b 1 |
| 700 | 1 | _ | |a Weber, Damien C |b 2 |
| 700 | 1 | _ | |a Jäkel, Oliver |0 P:(DE-He78)440a3f62ea9ea5c63375308976fc4c44 |b 3 |u dkfz |
| 700 | 1 | _ | |a Karger, Christian |0 P:(DE-He78)b43076fb0a30230e4323887c0c980046 |b 4 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.radonc.2018.01.018 |g Vol. 128, no. 1, p. 109 - 114 |0 PERI:(DE-600)1500707-8 |n 1 |p 109 - 114 |t Radiotherapy and oncology |v 128 |y 2018 |x 0167-8140 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:136861 |p VDB |
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