%0 Journal Article
%A Mokhtarzade, Motahare
%A Motl, Robert
%A Negaresh, Raoof
%A Zimmer, Philipp
%A Khodadoost, Mostafa
%A Baker, Julien S
%A Patel, Darpan
%A Majdinasab, Nastaran
%A Ranjbar, Rouholah
%T Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis.
%J Neuropeptides
%V 70
%@ 0143-4179
%C [New York, NY]
%I Elsevier
%M DKFZ-2018-01321
%P 93 - 100
%D 2018
%X Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60-70
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29880392
%R 10.1016/j.npep.2018.05.010
%U https://inrepo02.dkfz.de/record/136883