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000136883 0247_ $$2doi$$a10.1016/j.npep.2018.05.010
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000136883 1001_ $$aMokhtarzade, Motahare$$b0
000136883 245__ $$aExercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis.
000136883 260__ $$a[New York, NY]$$bElsevier$$c2018
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000136883 520__ $$aBlood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60-70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.
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000136883 7001_ $$aMotl, Robert$$b1
000136883 7001_ $$aNegaresh, Raoof$$b2
000136883 7001_ $$0P:(DE-He78)d05b24af674d8ef2c455634434b67770$$aZimmer, Philipp$$b3$$udkfz
000136883 7001_ $$aKhodadoost, Mostafa$$b4
000136883 7001_ $$aBaker, Julien S$$b5
000136883 7001_ $$aPatel, Darpan$$b6
000136883 7001_ $$aMajdinasab, Nastaran$$b7
000136883 7001_ $$aRanjbar, Rouholah$$b8
000136883 773__ $$0PERI:(DE-600)2002474-5$$a10.1016/j.npep.2018.05.010$$gVol. 70, p. 93 - 100$$p93 - 100$$tNeuropeptides$$v70$$x0143-4179$$y2018
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