TY  - JOUR
AU  - Mokhtarzade, Motahare
AU  - Motl, Robert
AU  - Negaresh, Raoof
AU  - Zimmer, Philipp
AU  - Khodadoost, Mostafa
AU  - Baker, Julien S
AU  - Patel, Darpan
AU  - Majdinasab, Nastaran
AU  - Ranjbar, Rouholah
TI  - Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis.
JO  - Neuropeptides
VL  - 70
SN  - 0143-4179
CY  - [New York, NY]
PB  - Elsevier
M1  - DKFZ-2018-01321
SP  - 93 - 100
PY  - 2018
AB  - Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60-70
LB  - PUB:(DE-HGF)16
C6  - pmid:29880392
DO  - DOI:10.1016/j.npep.2018.05.010
UR  - https://inrepo02.dkfz.de/record/136883
ER  -