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@ARTICLE{Mokhtarzade:136883,
      author       = {M. Mokhtarzade and R. Motl and R. Negaresh and P.
                      Zimmer$^*$ and M. Khodadoost and J. S. Baker and D. Patel
                      and N. Majdinasab and R. Ranjbar},
      title        = {{E}xercise-induced changes in neurotrophic factors and
                      markers of blood-brain barrier permeability are moderated by
                      weight status in multiple sclerosis.},
      journal      = {Neuropeptides},
      volume       = {70},
      issn         = {0143-4179},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-01321},
      pages        = {93 - 100},
      year         = {2018},
      abstract     = {Blood-brain barrier (BBB) and neurotrophic factors
                      seemingly have an important role in multiple sclerosis
                      pathology. Physical activity may influence blood-brain
                      barrier function and levels of neurotrophic factors, and
                      such effects might be moderated by body weight status. This
                      study investigated the effect of exercise training on
                      markers of blood-brain barrier permeability and neurotrophic
                      factors as a function of weight status in multiple sclerosis
                      patients. Sixty three persons with relapsing remitting
                      multiple sclerosis who were normal weight (n: 33) or
                      overweight (n: 33) were randomly assigned into groups of
                      exercise (normal weight training, n: 18; overweight training
                      group, n: 18) or no exercise (normal weight control, n: 15;
                      overweight control group, n: 15). The intervention consisted
                      of 8 weeks (3 days per week) of cycling undertaken at
                      $60-70\%$ peak power. Resting blood concentrations of s100
                      calcium-binding protein B (s100b) and neuron-specific
                      enolase as BBB permeability markers, neurotrophic factors
                      and cytokines (Interleukin-10 and tumor necrosis factor
                      alpha) were evaluated before and after the intervention.
                      There were significant weight, training, and interaction
                      effects on brain-derived neurotrophic factor and
                      platelet-derived growth factor; however, ciliary
                      neurotrophic factor and nerve growth factor did not
                      demonstrate any effect. Brain-derived neurotrophic factor
                      and platelet-derived growth factor were significantly
                      increased from pre-post in normal weight exercise.
                      Significant weight, training, and interaction effects were
                      found for s100b. In detail, s100b was significantly
                      increased from pre-post in normal weight exercise. In
                      contrast, neuron-specific enolase and cytokines did not
                      demonstrate any effect. Generally, Exercise training may
                      alter markers of BBB permeability and neurotrophic factor
                      status in normal weight persons with multiple sclerosis;
                      however, overweight participants may be more resistant to
                      these effects of exercise.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29880392},
      doi          = {10.1016/j.npep.2018.05.010},
      url          = {https://inrepo02.dkfz.de/record/136883},
}