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| Home > Publications database > Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis. > print |
| Home > Publications database > Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis. > print |
| 001 | 136883 | ||
| 005 | 20240229105105.0 | ||
| 024 | 7 | _ | |a 10.1016/j.npep.2018.05.010 |2 doi |
| 024 | 7 | _ | |a pmid:29880392 |2 pmid |
| 024 | 7 | _ | |a 0143-4179 |2 ISSN |
| 024 | 7 | _ | |a 1532-2785 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2018-01321 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Mokhtarzade, Motahare |b 0 |
| 245 | _ | _ | |a Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis. |
| 260 | _ | _ | |a [New York, NY] |c 2018 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1536226060_3628 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60-70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise. |
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| 700 | 1 | _ | |a Motl, Robert |b 1 |
| 700 | 1 | _ | |a Negaresh, Raoof |b 2 |
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| 700 | 1 | _ | |a Khodadoost, Mostafa |b 4 |
| 700 | 1 | _ | |a Baker, Julien S |b 5 |
| 700 | 1 | _ | |a Patel, Darpan |b 6 |
| 700 | 1 | _ | |a Majdinasab, Nastaran |b 7 |
| 700 | 1 | _ | |a Ranjbar, Rouholah |b 8 |
| 773 | _ | _ | |a 10.1016/j.npep.2018.05.010 |g Vol. 70, p. 93 - 100 |0 PERI:(DE-600)2002474-5 |p 93 - 100 |t Neuropeptides |v 70 |y 2018 |x 0143-4179 |
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