000136889 001__ 136889
000136889 005__ 20240229105105.0
000136889 0247_ $$2doi$$a10.1016/j.celrep.2018.07.069
000136889 0247_ $$2pmid$$apmid:30134159
000136889 0247_ $$2altmetric$$aaltmetric:46860373
000136889 037__ $$aDKFZ-2018-01327
000136889 041__ $$aeng
000136889 082__ $$a570
000136889 1001_ $$0P:(DE-He78)149f2a83a2f8e70d73a356e94cb6745a$$aRölle, Alexander$$b0$$eFirst author$$udkfz
000136889 245__ $$aDistinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.
000136889 260__ $$aMaryland Heights, MO$$bCell Press$$c2018
000136889 3367_ $$2DRIVER$$aarticle
000136889 3367_ $$2DataCite$$aOutput Types/Journal article
000136889 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1536654603_23574
000136889 3367_ $$2BibTeX$$aARTICLE
000136889 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000136889 3367_ $$00$$2EndNote$$aJournal Article
000136889 520__ $$aAdaptive NK cells are characterized by profound alterations in multiple signaling molecules, transcription factors, and epigenetic modifications compared with canonical NK cells. Although their existence is associated with prior exposure to human cytomegalovirus (HCMV), key questions regarding their regulation and function remain. A large proportion of adaptive NK cells express the activating receptor CD94/NKG2C, binding to human leukocyte antigen E (HLA-E), that presents a limited set of peptides. We show that adaptive NK cells discriminate differences between HLA-E-peptide complexes with exquisite specificity. Prolonged exposure to an environment displaying the HLA-E peptide ligand VMAPRTLFL, derived from the leader sequence of HLA-G, enriched adaptive NK cells with low FcεRγ expression, upregulated CD25 expression, increased proliferative activity, and resulted in elevated antibody-dependent cellular cytotoxicity and IFN-γ responses compared with other HLA-E peptide complexes. Our study demonstrates that recognition of alterations in the HLA-E ligandome via an activating receptor can influence heterologous effector mechanisms and proliferation in adaptive NK cells.
000136889 536__ $$0G:(DE-HGF)POF3-314$$a314 - Tumor immunology (POF3-314)$$cPOF3-314$$fPOF III$$x0
000136889 588__ $$aDataset connected to CrossRef, PubMed,
000136889 7001_ $$0P:(DE-He78)27b8b96bde8e36bbbc5e91485b08411a$$aMeyer, Marten$$b1$$udkfz
000136889 7001_ $$0P:(DE-HGF)0$$aCalderazzo, Silvia$$b2
000136889 7001_ $$0P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aJäger, Dirk$$b3$$udkfz
000136889 7001_ $$0P:(DE-He78)b2290261145f21c46f2d42783c69d104$$aMomburg, Frank$$b4$$eLast author$$udkfz
000136889 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2018.07.069$$gVol. 24, no. 8, p. 1967 - 1976.e4$$n8$$p1967 - 1976.e4$$tCell reports$$v24$$x2211-1247$$y2018
000136889 909CO $$ooai:inrepo02.dkfz.de:136889$$pVDB
000136889 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)149f2a83a2f8e70d73a356e94cb6745a$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000136889 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)27b8b96bde8e36bbbc5e91485b08411a$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000136889 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000136889 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000136889 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b2290261145f21c46f2d42783c69d104$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000136889 9131_ $$0G:(DE-HGF)POF3-314$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTumor immunology$$x0
000136889 9141_ $$y2018
000136889 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCELL REP : 2015
000136889 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000136889 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000136889 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000136889 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000136889 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000136889 915__ $$0LIC:(DE-HGF)CCBYNCNDNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND (No Version)$$bDOAJ
000136889 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000136889 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000136889 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000136889 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000136889 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCELL REP : 2015
000136889 9201_ $$0I:(DE-He78)D121-20160331$$kD121$$lAG Antigenpräsentation und T/NK-Zell-Aktivierung$$x0
000136889 9201_ $$0I:(DE-He78)C060-20160331$$kC060$$lBiostatistik$$x1
000136889 9201_ $$0I:(DE-He78)D120-20160331$$kD120$$lAngewandte Tumor-Immunität$$x2
000136889 980__ $$ajournal
000136889 980__ $$aVDB
000136889 980__ $$aI:(DE-He78)D121-20160331
000136889 980__ $$aI:(DE-He78)C060-20160331
000136889 980__ $$aI:(DE-He78)D120-20160331
000136889 980__ $$aUNRESTRICTED