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@ARTICLE{OMara:136921,
      author       = {T. A. O'Mara and D. M. Glubb and F. Amant and D. Annibali
                      and K. Ashton and J. Attia and P. L. Auer and M. W. Beckmann
                      and A. Black and M. K. Bolla and H. Brauch$^*$ and H.
                      Brenner$^*$ and L. Brinton and D. D. Buchanan and B.
                      Burwinkel$^*$ and J. Chang-Claude$^*$ and S. J. Chanock and
                      C. Chen and M. M. Chen and T. H. T. Cheng and C. L. Clarke
                      and M. Clendenning and L. S. Cook and F. J. Couch and A. Cox
                      and M. Crous-Bous and K. Czene and F. Day and J. Dennis and
                      J. Depreeuw and J. A. Doherty and T. Dörk and S. C. Dowdy
                      and M. Dürst and A. B. Ekici and P. A. Fasching and B. L.
                      Fridley and C. M. Friedenreich and L. Fritschi and J. Fung
                      and M. García-Closas and M. M. Gaudet and G. G. Giles and
                      E. L. Goode and M. Gorman and C. A. Haiman and P. Hall and
                      S. E. Hankison and C. S. Healey and A. Hein and P.
                      Hillemanns and S. Hodgson and E. A. Hoivik and E. G.
                      Holliday and J. L. Hopper and D. J. Hunter and A. Jones and
                      C. Krakstad and V. N. Kristensen and D. Lambrechts and L. L.
                      Marchand and X. Liang and A. Lindblom and J. Lissowska and
                      J. Long and L. Lu and A. M. Magliocco and L. Martin and M.
                      McEvoy and A. Meindl and K. Michailidou and R. L. Milne and
                      M. Mints and G. W. Montgomery and R. Nassir and H. Olsson
                      and I. Orlow and G. Otton and C. Palles and J. R. B. Perry
                      and J. Peto and L. Pooler and J. Prescott and T. Proietto
                      and T. R. Rebbeck and H. A. Risch and P. A. W. Rogers and M.
                      Rübner and I. Runnebaum and C. Sacerdote and G. E. Sarto
                      and F. Schumacher and R. J. Scott and V. W. Setiawan and M.
                      Shah and X. Sheng and X.-O. Shu and M. C. Southey and A. J.
                      Swerdlow and E. Tham and J. Trovik and C. Turman and J. P.
                      Tyrer and C. Vachon and D. VanDen Berg and A. Vanderstichele
                      and Z. Wang and P. M. Webb and N. Wentzensen and H. M. J.
                      Werner and S. J. Winham and A. Wolk and L. Xia and Y.-B.
                      Xiang and H. P. Yang and H. Yu and W. Zheng and P. D. P.
                      Pharoah and A. M. Dunning and P. Kraft and I. De Vivo and I.
                      Tomlinson and D. F. Easton and A. B. Spurdle and D. J.
                      Thompson},
      title        = {{I}dentification of nine new susceptibility loci for
                      endometrial cancer.},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2018-01358},
      pages        = {3166},
      year         = {2018},
      abstract     = {Endometrial cancer is the most commonly diagnosed cancer of
                      the female reproductive tract in developed countries.
                      Through genome-wide association studies (GWAS), we have
                      previously identified eight risk loci for endometrial
                      cancer. Here, we present an expanded meta-analysis of 12,906
                      endometrial cancer cases and 108,979 controls (including new
                      genotype data for 5624 cases) and identify nine novel
                      genome-wide significant loci, including a locus on 12q24.12
                      previously identified by meta-GWAS of endometrial and
                      colorectal cancer. At five loci, expression quantitative
                      trait locus (eQTL) analyses identify candidate causal genes;
                      risk alleles at two of these loci associate with decreased
                      expression of genes, which encode negative regulators of
                      oncogenic signal transduction proteins (SH2B3 (12q24.12) and
                      NF1 (17q11.2)). In summary, this study has doubled the
                      number of known endometrial cancer risk loci and revealed
                      candidate causal genes for future study.},
      cin          = {L801 / C070 / G110 / L101 / C080 / C020},
      ddc          = {500},
      cid          = {I:(DE-He78)L801-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)G110-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)C080-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30093612},
      pmc          = {pmc:PMC6085317},
      doi          = {10.1038/s41467-018-05427-7},
      url          = {https://inrepo02.dkfz.de/record/136921},
}