TY  - JOUR
AU  - Qian, Jing
AU  - Tikk, Kaja
AU  - Werner, Simone
AU  - Balavarca, Yesilda
AU  - Saadati, Maral
AU  - Hechtner, Marlene
AU  - Brenner, Hermann
TI  - Biomarker discovery study of inflammatory proteins for colorectal cancer early detection demonstrated importance of screening setting validation.
JO  - Journal of clinical epidemiology
VL  - 104
SN  - 0895-4356
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2018-01360
SP  - 24 - 34
PY  - 2018
AB  - Most studies identifying inflammatory markers for early detection of colorectal cancer (CRC) were conducted using clinically manifest cases. We aimed to identify circulating inflammatory biomarkers for early detection of CRC and validate them in both a clinical setting and a true screening setting.A total of 92 inflammatory proteins were quantified in baseline plasma samples from individuals clinically diagnosed with CRC and neoplasm-free controls matched on age and sex (training set). A multi-marker panel was selected and evaluated in samples from another clinical setting (validation set C) and a screening setting (validation set S).In the training set (n=330) a 5-biomarker signature was selected that provided an AUC of 0.85 and 60.9
LB  - PUB:(DE-HGF)16
C6  - pmid:30076979
DO  - DOI:10.1016/j.jclinepi.2018.07.016
UR  - https://inrepo02.dkfz.de/record/136923
ER  -