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@ARTICLE{Sarink:136927,
      author       = {D. Sarink$^*$ and L. Nedkoff and T. Briffa and J. E. Shaw
                      and D. J. Magliano and C. Stevenson and H. Mannan and M.
                      Knuiman and J. Hung and G. J. Hankey and P. Norman and A.
                      Peeters},
      title        = {{T}rends in age- and sex-specific prevalence and incidence
                      of cardiovascular disease in {W}estern {A}ustralia.},
      journal      = {European journal of preventive cardiology},
      volume       = {25},
      number       = {12},
      issn         = {2047-4881},
      address      = {London [u.a.]},
      publisher    = {Sage Publ.},
      reportid     = {DKFZ-2018-01364},
      pages        = {1280 - 1290},
      year         = {2018},
      abstract     = {Background Temporal trends in incidence and mortality of
                      cardiovascular disease (CVD) have been well described, with
                      recent data suggesting declining improvements in those aged
                      under 55 years. However, little is known about the combined
                      impact of incidence and mortality trends on disease
                      prevalence, an important indicator of disease burden and
                      cost. We analysed changes in age-specific and
                      age-standardised temporal trends in prevalence and incidence
                      of CVD subtypes. Methods Annual prevalence and incidence
                      rates of coronary heart disease, cerebrovascular disease and
                      peripheral arterial disease for the Western Australian
                      population for 1995-2010 were calculated using data from the
                      Western Australian Data Linkage System. Joinpoint regression
                      analyses were used to identify joinpoints in trends in
                      age-specific and age-standardised annual prevalence and
                      incidence rates for each CVD subtype. Results Between 1995
                      and 2010, age- and sex-specific incidence and prevalence of
                      the CVD subtypes generally decreased among middle-aged and
                      older adults, but were stable or increased among younger
                      adults. In < 55 year olds, increases in incidence tended
                      to occur from 2003, while increases in prevalence were from
                      2007/2008. Declines in age-standardised incidence were
                      greater than those in crude incidence, with changes in
                      population structure having a greater impact among men than
                      women. Conclusions The majority of CVDs occurs in older
                      adults. Our findings of generally worsening trends in
                      prevalence in younger adults across most CVD subtypes were
                      in contrast to generally declining trends in older age
                      groups. These data highlight the importance of monitoring
                      prevalence and incidence, particularly in younger adults.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30012003},
      doi          = {10.1177/2047487318786585},
      url          = {https://inrepo02.dkfz.de/record/136927},
}