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@ARTICLE{Bulut:136944,
      author       = {O. C. Bulut and S. Haufe and R. Hohenberger and M. Hein and
                      C. Kratochwil and H. Rathke and P. K. Plinkert and I.
                      Baumann and T. Holland-Letz$^*$ and U. Haberkorn and P.
                      Flechsig},
      title        = {{I}mpact of sialendoscopy on improving health related
                      quality of life in patients suffering from
                      radioiodineinduced xerostomia.},
      journal      = {Nuklearmedizin},
      volume       = {57},
      number       = {4},
      issn         = {0029-5566},
      address      = {Stuttgart},
      publisher    = {Schattauer},
      reportid     = {DKFZ-2018-01373},
      pages        = {160-167},
      year         = {2018},
      abstract     = {Xerostomia following radioiodine therapy (RIT) in patients
                      suffering from differentiated thyroid cancer is a common
                      side effect in 2 $\%$ to 67 $\%$ of patients treated with
                      radioiodine (I-131). In order to evaluate the impact of
                      sialendoscopy on health related quality of life (HRQOL) in
                      patients suffering from therapy induced sialadenitis and
                      xerostomia, we analyzed findings from two dedicated
                      questionnaires (Xerostomy Questionnaire XQ and Xerostomy
                      Inventory XI) in patients before and three months after
                      sialendoscopy.In total, 12 patients suffering from
                      differentiated thyroid carcinoma (10 women and 2 men) were
                      evaluated. All patients had experienced conservative
                      management. Patients were offered a sialendoscopy procedure
                      if no major contradictions were present. Patients who denied
                      the procedure formed the control group. Pre- and (three
                      months) postoperative HRQOL was measured with the Patient
                      Reported Outcome Measures (PROM) Xerostomia Questionnaire
                      (XQ) and the Xerostomia Inventory (XI), as well as by a pre-
                      and post-interventional salivary gland scintigram. Patients
                      were graded according to their sialendoscopical
                      findings.Interventional group presented with significant
                      improvements in HRQOL measurements regarding XQ and
                      XI-scores three months postoperatively. Control group showed
                      no significant changes in the XQ or the XI scores. Number of
                      RIT and cumulative activity of I-131 did not correlate with
                      higher disease grade in regards to sialendoscopical findings
                      nor did it correlate with higher XQand XI scores. Pre- and
                      post-interventional salivary gland scintigram stated that
                      parotid glands are more severely damaged than submandibular
                      glands (SMG), but no significant scintigraphically changes
                      could be detected after sialendoscopy.Sialendoscopy in
                      patients suffering from therapy induced sialadenitis and
                      xerostomia seems to be beneficial when evaluating the impact
                      on HRQOL. Functional parameters measured by salivary gland
                      scintigram did not show significant changes in
                      post-interventional scintigrams.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30125928},
      url          = {https://inrepo02.dkfz.de/record/136944},
}