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@ARTICLE{Stocker:136970,
      author       = {H. Stocker$^*$ and T. Möllers$^*$ and L. Perna$^*$ and H.
                      Brenner$^*$},
      title        = {{T}he genetic risk of {A}lzheimers disease beyond {APOE}
                      ε4: systematic review of {A}lzheimers genetic risk scores.},
      journal      = {Translational Psychiatry},
      volume       = {8},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2018-01399},
      pages        = {166},
      year         = {2018},
      abstract     = {The ε4 allele of Apolipoprotein E (APOE) is the strongest
                      known genetic risk factor of Alzheimer's disease (AD) but
                      does not account for the entirety of genetic risk. Genetic
                      risk scores (GRSs) incorporating additional genetic variants
                      have been developed to determine the genetic risk for AD,
                      yet there is no systematic review assessing the contribution
                      of GRSs for AD beyond the effect of APOE ε4. The purpose of
                      this systematic PRISMA (Preferred Reporting Items for
                      Systematic Reviews and Meta-analyses)-based review was to
                      summarize original research studies that have developed and
                      validated a GRS for AD utilizing associated single
                      nucleotide polymorphisms (SNPs). The PubMed and Web of
                      Science databases were searched on April 6, 2018 and
                      screening was completed on 2018 citations by two independent
                      reviewers. Eighteen studies published between 2010 and 2018
                      were included in the review. All GRSs expressed significant
                      associations or discrimination capability of AD when
                      compared to clinically normal controls; however, GRS
                      prediction of MCI to AD conversion was mixed. APOE ε4
                      status was more predictive of AD than the GRSs, although the
                      GRSs did add to AD prediction accuracy beyond APOE ε4. GRSs
                      might contribute to identifying genetic risk of AD beyond
                      APOE. However, additional studies are warranted to assess
                      the performance of GRSs in independent longitudinal
                      cohorts.},
      subtyp        = {Review Article},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30143603},
      pmc          = {pmc:PMC6109140},
      doi          = {10.1038/s41398-018-0221-8},
      url          = {https://inrepo02.dkfz.de/record/136970},
}