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@ARTICLE{Cairat:136991,
      author       = {M. Cairat and A. Fournier and N. Murphy and C. Biessy and
                      A. Scalbert and S. Rinaldi and A. Tjønneland and A. Olsen
                      and K. Overvad and P. Arveux and M.-C. Boutron-Ruault and C.
                      Cadeau and R. Turzanski-Fortner$^*$ and R. Kaaks$^*$ and H.
                      Boeing and K. Aleksandrova and P. H. M. Peeters and C. H.
                      Van Gils and N. J. Wareham and K.-T. Khaw and D. Aune and E.
                      Riboli and M. J. Gunter and L. Dossus},
      title        = {{N}onsteroidal anti-inflammatory drug use and breast cancer
                      risk in a {E}uropean prospective cohort study.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {7},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01419},
      pages        = {1688 - 1695},
      year         = {2018},
      abstract     = {Experimental studies have shown a protective effect of
                      nonsteroidal anti-inflammatory drugs (NSAIDs) on breast
                      cancer development. However, results from epidemiological
                      cohort studies are less consistent. Our objective was to
                      assess the association between NSAID use and breast cancer
                      risk within the European Prospective Investigation into
                      Cancer and Nutrition (EPIC). EPIC is a prospective cohort
                      study initiated in 1992 in 10 European countries.
                      Self-reported information on NSAID use at baseline has been
                      collected in five EPIC countries. Multivariable Cox
                      regression models were used to estimate hazard ratios for
                      the association of NSAID use with breast cancer incidence
                      with adjustment for potential confounders. We also assessed
                      effect modification by breast cancer risk factors and
                      examined the associations within specific breast cancer
                      subtypes. Among the 140,981 women included in the analysis,
                      $7\%$ were regularly using NSAIDs at baseline. During a
                      median follow-up time period of 13 years, 7,379 incident
                      breast cancer cases were diagnosed (816 in situ and 6,563
                      invasive). There were no statistically significant
                      associations between NSAID use and breast cancer risk,
                      overall and by subtypes. However, a statistically
                      significant interaction was observed for invasive cases
                      between NSAID use and ever use of menopausal hormonal
                      therapy (MHT) among postmenopausal women [MHT users: HRNSAID
                      use  = 0.84 (0.73-0.96); non MHT users: HRNSAID use
                       = 1.08 (0.93-1.25); pinteraction  = 0.05]. Our
                      results indicate potential effect modification of MHT use on
                      the association between use of NSAIDs and breast cancer risk
                      which deserves in-depth investigation in studies with
                      accurate data on both NSAID and MHT use.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29707771},
      doi          = {10.1002/ijc.31570},
      url          = {https://inrepo02.dkfz.de/record/136991},
}