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@ARTICLE{Murphy:137000,
      author       = {N. Murphy and D. Achaintre and R. Zamora-Ros and M. Jenab
                      and M.-C. Boutron-Ruault and F. Carbonnel and I. Savoye and
                      R. Kaaks$^*$ and T. Kühn$^*$ and H. Boeing and K.
                      Aleksandrova and A. Tjønneland and C. Kyrø and K. Overvad
                      and J. R. Quirós and M.-J. Sánchez and J. M. Altzibar and
                      J. María Huerta and A. Barricarte and K.-T. Khaw and K. E.
                      Bradbury and A. Perez-Cornago and A. Trichopoulou and A.
                      Karakatsani and E. Peppa and D. Palli and S. Grioni and R.
                      Tumino and C. Sacerdote and S. Panico and H. B. A.
                      Bueno-de-Mesquita and P. H. Peeters and M. Rutegård and I.
                      Johansson and H. Freisling and H. Noh and A. J. Cross and P.
                      Vineis and K. Tsilidis and M. J. Gunter and A. Scalbert},
      title        = {{A} prospective evaluation of plasma polyphenol levels and
                      colon cancer risk.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {7},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01428},
      pages        = {1620 - 1631},
      year         = {2018},
      abstract     = {Polyphenols have been shown to exert biological activity in
                      experimental models of colon cancer; however, human data
                      linking specific polyphenols to colon cancer is limited. We
                      assessed the relationship between pre-diagnostic plasma
                      polyphenols and colon cancer risk in a case-control study
                      nested within the European Prospective Investigation into
                      Cancer and Nutrition study. Using high pressure liquid
                      chromatography coupled to tandem mass spectrometry, we
                      measured concentrations of 35 polyphenols in plasma from 809
                      incident colon cancer cases and 809 matched controls. We
                      used multivariable adjusted conditional logistic regression
                      models that included established colon cancer risk factors.
                      The false discovery rate (qvalues ) was computed to control
                      for multiple comparisons. All statistical tests were
                      two-sided. After false discovery rate correction and in
                      continuous log2 -transformed multivariable models, equol
                      (odds ratio [OR] per log2 -value, 0.86, $95\%$ confidence
                      interval $[95\%$ CI] = 0.79-0.93; qvalue  = 0.01)
                      and homovanillic acid (OR per log2 -value, 1.46, $95\%$
                      CI = 1.16-1.84; qvalue  = 0.02) were associated with
                      colon cancer risk. Comparing extreme fifths, equol
                      concentrations were inversely associated with colon cancer
                      risk (OR = 0.61, $95\%$ CI = 0.41-0.91, ptrend
                       = 0.003), while homovanillic acid concentrations were
                      positively associated with colon cancer development
                      (OR = 1.72, $95\%$ CI = 1.17-2.53, ptrend
                       < 0.0001). No heterogeneity for these associations was
                      observed by sex and across other colon cancer risk factors.
                      The remaining polyphenols were not associated with colon
                      cancer risk. Higher equol concentrations were associated
                      with lower risk, and higher homovanillic acid concentrations
                      were associated with greater risk of colon cancer. These
                      findings support a potential role for specific polyphenols
                      in colon tumorigenesis.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29696648},
      doi          = {10.1002/ijc.31563},
      url          = {https://inrepo02.dkfz.de/record/137000},
}