% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Negaresh:137001,
      author       = {R. Negaresh and R. W. Motl and M. Mokhtarzade and U. Dalgas
                      and D. Patel and M. M. Shamsi and N. Majdinasab and R.
                      Ranjbar and P. Zimmer$^*$ and J. S. Baker$^*$},
      title        = {{E}ffects of exercise training on cytokines and adipokines
                      in multiple {S}clerosis: {A} systematic review.},
      journal      = {Multiple Sclerosis and Related Disorders},
      volume       = {24},
      issn         = {2211-0348},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-01429},
      pages        = {91 - 100},
      year         = {2018},
      abstract     = {Physical activity, particularly exercise training, is an
                      evidence-based approach for managing symptoms, restoring
                      function and improving overall wellness in people with
                      multiple sclerosis (MS). Several recent studies have argued
                      for a potential disease modifying effect of exercise in
                      people with MS, and among the potential mediating mechanisms
                      are exercise training effects on both cytokines and
                      adipokines. The objectives of this study were to perform a
                      systematic review of exercise training effects on cytokine
                      and adipokine profiles in persons with MS.We conducted
                      open-dated searches of PubMed, Cochrane Library, EMBASE and
                      PEDro using the terms Multiple sclerosis or MS AND exercise
                      OR training OR physical activity AND cytokine OR
                      inflammatory OR immune OR adipokine. Included studies were
                      written in English; comprised of humans with MS, and
                      evaluated the effects of regular physical activity or
                      exercise on pro-inflammatory, anti-inflammatory cytokines or
                      adipokines. Two authors independently scanned titles and
                      abstracts, and read the studies included. All studies were
                      rated on the PEDro scale and further classified based on
                      American Academy of Neurology criteria.Twelve studies were
                      included of which 10 studies focused on cytokines, 1 study
                      focused on adipokines, and 1 study included both cytokines
                      and adipokines. The selected studies included 3 Class I
                      studies, 7 Class II studies, and 2 Class IV studies and had
                      average PEDro scores of 6.9 ± 1.6. Studies included
                      endurance (n = 5), resistance (n = 3), combined
                      (n = 3), and vibration (n = 1) training. Overall,
                      there is a general lack of standardization of procedures
                      across studies and inconsistent evidence for the effects of
                      physical activity and exercise on cytokine and adipokine
                      profiles in MS, with a general pattern indicating a lack of
                      effect.Research regarding the effects of exercise training
                      on cytokines and adipokines in MS is in its infancy, but
                      exercise represents an adjuvant therapy in MS, and future
                      studies are essential for clarifying the role of exercise on
                      cytokines and adipokines in MS.},
      subtyp        = {Review Article},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29982111},
      doi          = {10.1016/j.msard.2018.06.008},
      url          = {https://inrepo02.dkfz.de/record/137001},
}