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@ARTICLE{Kordass:137560,
      author       = {T. Kordass$^*$ and C. E. M. Weber$^*$ and D. Eisel$^*$ and
                      A. Pane$^*$ and W. Osen$^*$ and S. Eichmüller$^*$},
      title        = {mi{R}-193b and mi{R}-30c-1* inhibit, whereas mi{R}-576-5p
                      enhances melanoma cell invasion in vitro.},
      journal      = {OncoTarget},
      volume       = {9},
      number       = {65},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2018-01440},
      pages        = {32507-32522},
      year         = {2018},
      abstract     = {In cancer cells, microRNAs (miRNAs) are often aberrantly
                      expressed resulting in impaired mRNA translation. In this
                      study we show that miR-193b and miR-30c-1* inhibit, whereas
                      miR-576-5p accelerates invasion of various human melanoma
                      cell lines. Using Boyden chamber invasion assays the effect
                      of selected miRNAs on the invasive capacity of various human
                      melanoma cell lines was analyzed. Upon gene expression
                      profiling performed on transfected A375 cells, CTGF, THBS1,
                      STMN1, BCL9, RAC1 and MCL1 were identified as potential
                      targets. For target validation, qPCR, Western blot analyses
                      or luciferase reporter assays were applied. This study
                      reveals opposed effects of miR-193b / miR-30c-1* and
                      miR-576-5p, respectively, on melanoma cell invasion and on
                      expression of BCL9 and MCL1, possibly accounting for the
                      contrasting invasive phenotypes observed in A375 cells
                      transfected with these miRNAs. The miRNAs studied and their
                      targets identified fit well into a model proposed by us
                      explaining the regulation of invasion associated genes and
                      the observed opposed phenotypes as a result of networked
                      direct and indirect miRNA / target interactions. The results
                      of this study suggest miR-193b and miR-30c-1* as
                      tumor-suppressive miRNAs, whereas miR-576-5p appears as
                      potential tumor-promoting oncomiR. Thus, miR-193b and
                      miR-30c-1* mimics as well as antagomiRs directed against
                      miR-576-5p might become useful tools in future therapy
                      approaches against advanced melanoma.},
      cin          = {G182},
      ddc          = {610},
      cid          = {I:(DE-He78)G182-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30197759},
      pmc          = {pmc:PMC6126698},
      doi          = {10.18632/oncotarget.25986},
      url          = {https://inrepo02.dkfz.de/record/137560},
}