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000137570 1001_ $$aHeinrichs, Sophie K M$$b0
000137570 245__ $$aEvidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.
000137570 260__ $$aHoboken, NJ$$bWiley$$c2018
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000137570 520__ $$aGenetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 × 10-04 ) and on chromosome 8q24 at rs2585176 (P = 1.09 × 10-09 ). On chromosome 5p13 we found cis-eQTL effects with an upregulation of PTGER4 expression in GC risk allele carrier (P = 9.27 × 10-11 ). On chromosome 8q24 we observed cis-eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 × 10-47 ). In addition, we found trans-eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 × 10-09 ). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring GC pathomechanisms.
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000137570 7001_ $$aHess, Timo$$b1
000137570 7001_ $$aBecker, Jessica$$b2
000137570 7001_ $$aHamann, Lutz$$b3
000137570 7001_ $$aVashist, Yogesh K$$b4
000137570 7001_ $$0P:(DE-He78)7ca7eafba864e5c3ebb7598149380452$$aButterbach, Katja$$b5$$udkfz
000137570 7001_ $$00000-0002-7166-3675$$aSchmidt, Thomas$$b6
000137570 7001_ $$aAlakus, Hakan$$b7
000137570 7001_ $$aKrasniuk, Iurii$$b8
000137570 7001_ $$aHöblinger, Aksana$$b9
000137570 7001_ $$aLingohr, Philipp$$b10
000137570 7001_ $$aLudwig, Monika$$b11
000137570 7001_ $$aHagel, Alexander F$$b12
000137570 7001_ $$aSchildberg, Claus W$$b13
000137570 7001_ $$aVeits, Lothar$$b14
000137570 7001_ $$aGyvyte, Ugne$$b15
000137570 7001_ $$aWeise, Katharina$$b16
000137570 7001_ $$aSchüller, Vitalia$$b17
000137570 7001_ $$aBöhmer, Anne C$$b18
000137570 7001_ $$aSchröder, Julia$$b19
000137570 7001_ $$aGehlen, Jan$$b20
000137570 7001_ $$aKreuser, Nicole$$b21
000137570 7001_ $$aHofer, Sebastian$$b22
000137570 7001_ $$aLang, Hauke$$b23
000137570 7001_ $$aLordick, Florian$$b24
000137570 7001_ $$aMalfertheiner, Peter$$b25
000137570 7001_ $$aMoehler, Markus$$b26
000137570 7001_ $$aPech, Oliver$$b27
000137570 7001_ $$aVassos, Nikolaos$$b28
000137570 7001_ $$aRodermann, Ernst$$b29
000137570 7001_ $$aIzbicki, Jakob R$$b30
000137570 7001_ $$aKruschewski, Martin$$b31
000137570 7001_ $$aOtt, Katja$$b32
000137570 7001_ $$aSchumann, Ralf R$$b33
000137570 7001_ $$aVieth, Michael$$b34
000137570 7001_ $$aMangold, Elisabeth$$b35
000137570 7001_ $$aGasenko, Evita$$b36
000137570 7001_ $$aKupcinskas, Limas$$b37
000137570 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b38$$udkfz
000137570 7001_ $$aGrimminger, Peter$$b39
000137570 7001_ $$aBujanda, Luis$$b40
000137570 7001_ $$aSopeña, Federico$$b41
000137570 7001_ $$aEspinel, Jesús$$b42
000137570 7001_ $$aThomson, Concha$$b43
000137570 7001_ $$aPérez-Aísa, Ángeles$$b44
000137570 7001_ $$aCampo, Rafael$$b45
000137570 7001_ $$aGeijo, Fernando$$b46
000137570 7001_ $$aCollette, Daniela$$b47
000137570 7001_ $$aBruns, Christiane$$b48
000137570 7001_ $$aMesserle, Katharina$$b49
000137570 7001_ $$aGockel, Ines$$b50
000137570 7001_ $$aNöthen, Markus M$$b51
000137570 7001_ $$aLippert, Hans$$b52
000137570 7001_ $$aRidwelski, Karsten$$b53
000137570 7001_ $$aLanas, Angel$$b54
000137570 7001_ $$aKeller, Gisela$$b55
000137570 7001_ $$aKnapp, Michael$$b56
000137570 7001_ $$aLeja, Marcis$$b57
000137570 7001_ $$aKupcinskas, Juozas$$b58
000137570 7001_ $$aGarcía-González, Maria A$$b59
000137570 7001_ $$aVenerito, Marino$$b60
000137570 7001_ $$00000-0001-9217-6457$$aSchumacher, Johannes$$b61
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