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@ARTICLE{Heinrichs:137570,
      author       = {S. K. M. Heinrichs and T. Hess and J. Becker and L. Hamann
                      and Y. K. Vashist and K. Butterbach$^*$ and T. Schmidt and
                      H. Alakus and I. Krasniuk and A. Höblinger and P. Lingohr
                      and M. Ludwig and A. F. Hagel and C. W. Schildberg and L.
                      Veits and U. Gyvyte and K. Weise and V. Schüller and A. C.
                      Böhmer and J. Schröder and J. Gehlen and N. Kreuser and S.
                      Hofer and H. Lang and F. Lordick and P. Malfertheiner and M.
                      Moehler and O. Pech and N. Vassos and E. Rodermann and J. R.
                      Izbicki and M. Kruschewski and K. Ott and R. R. Schumann and
                      M. Vieth and E. Mangold and E. Gasenko and L. Kupcinskas and
                      H. Brenner$^*$ and P. Grimminger and L. Bujanda and F.
                      Sopeña and J. Espinel and C. Thomson and Á. Pérez-Aísa
                      and R. Campo and F. Geijo and D. Collette and C. Bruns and
                      K. Messerle and I. Gockel and M. M. Nöthen and H. Lippert
                      and K. Ridwelski and A. Lanas and G. Keller and M. Knapp and
                      M. Leja and J. Kupcinskas and M. A. García-González and M.
                      Venerito and J. Schumacher},
      title        = {{E}vidence for {PTGER}4, {PSCA}, and {MBOAT}7 as risk genes
                      for gastric cancer on the genome and transcriptome level.},
      journal      = {Cancer medicine},
      volume       = {7},
      number       = {10},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2018-01450},
      pages        = {5057-5065},
      year         = {2018},
      abstract     = {Genetic associations between variants on chromosome 5p13
                      and 8q24 and gastric cancer (GC) have been previously
                      reported in the Asian population. We aimed to replicate
                      these findings and to characterize the associations at the
                      genome and transcriptome level. We performed a fine-mapping
                      association study in 1926 GC patients and 2012 controls of
                      European descent using high dense SNP marker sets on both
                      chromosomal regions. Next, we performed expression
                      quantitative trait locus (eQTL) analyses using gastric
                      transcriptome data from 143 individuals focusing on the GC
                      associated variants. On chromosome 5p13 the strongest
                      association was observed at rs6872282 (P = 2.53 × 10-04
                      ) and on chromosome 8q24 at rs2585176 (P = 1.09 × 10-09
                      ). On chromosome 5p13 we found cis-eQTL effects with an
                      upregulation of PTGER4 expression in GC risk allele carrier
                      (P = 9.27 × 10-11 ). On chromosome 8q24 we observed
                      cis-eQTL effects with an upregulation of PSCA expression in
                      GC risk allele carrier (P = 2.17 × 10-47 ). In
                      addition, we found trans-eQTL effects for the same variants
                      on 8q24 with a downregulation of MBOAT7 expression in GC
                      risk allele carrier (P = 3.11 × 10-09 ). In summary, we
                      confirmed and refined the previously reported GC
                      associations at both chromosomal regions. Our data point to
                      shared etiological factors between Asians and Europeans.
                      Furthermore, our data imply an upregulated expression of
                      PTGER4 and PSCA as well as a downregulated expression of
                      MBOAT7 in gastric tissue as risk-conferring GC
                      pathomechanisms.},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30191681},
      doi          = {10.1002/cam4.1719},
      url          = {https://inrepo02.dkfz.de/record/137570},
}