TY  - JOUR
AU  - Dai, James Y
AU  - Peters, Ulrike
AU  - Wang, Xiaoyu
AU  - Kocarnik, Jonathan
AU  - Chang-Claude, Jenny
AU  - Slattery, Martha L
AU  - Chan, Andrew
AU  - Lemire, Mathieu
AU  - Berndt, Sonja I
AU  - Casey, Graham
AU  - Song, Mingyang
AU  - Jenkins, Mark A
AU  - Brenner, Hermann
AU  - Thrift, Aaron P
AU  - White, Emily
AU  - Hsu, Li
TI  - Diagnostics of Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects.
JO  - American journal of epidemiology
VL  - 187
SN  - 1476-6256
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2018-01458
SP  - 2672-2680
PY  - 2018
AB  - Diagnosing pleiotropy is critical for assessing the validity of Mendelian randomization (MR) analyses. The popular MR-Egger method evaluates whether there is evidence of bias-generating pleiotropy among a set of candidate genetic instrumental variables. In this article, we propose GLIDE, GLobal and Individual tests for Direct Effects, a statistical method to systematically evaluate pleiotropy among the set of genetic variants, e.g., single nucleotide polymorphisms (SNPs), used for MR. As a global test, simulation experiments suggest that GLIDE is nearly uniformly more powerful than the MR-Egger method. As a sensitivity analysis, GLIDE is capable of detecting outliers in individual variant-level pleiotropy, in order to obtain a refined set of genetic instrumental variables. We used GLIDE to analyze both body-mass index and height for risk of colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium. Among the body mass index associated SNPs and the height associated SNPs, several individual variants showed evidence of pleiotropy. Removal of these potentially pleiotropic SNPs resulted in attenuation of respective estimates of the causal effects. In summary, the proposed GLIDE method is useful for sensitivity analyses and improves the validity of MR.
LB  - PUB:(DE-HGF)16
C6  - pmid:30188971
DO  - DOI:10.1093/aje/kwy177
UR  - https://inrepo02.dkfz.de/record/137578
ER  -