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000137585 1001_ $$aSweegers, Maike G$$b0
000137585 245__ $$aEffects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data.
000137585 260__ $$aLondon$$bBMJ Publ. Group$$c2019
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000137585 520__ $$aTo optimally target exercise interventions for patients with cancer, it is important to identify which patients benefit from which interventions.We conducted an individual patient data meta-analysis to investigate demographic, clinical, intervention-related and exercise-related moderators of exercise intervention effects on physical fitness in patients with cancer.We identified relevant studies via systematic searches in electronic databases (PubMed, Embase, PsycINFO and CINAHL).We analysed data from 28 randomised controlled trials investigating the effects of exercise on upper body muscle strength (UBMS) and lower body muscle strength (LBMS), lower body muscle function (LBMF) and aerobic fitness in adult patients with cancer.Exercise significantly improved UBMS (β=0.20, 95% Confidence Interval (CI) 0.14 to 0.26), LBMS (β=0.29, 95% CI 0.23 to 0.35), LBMF (β=0.16, 95% CI 0.08 to 0.24) and aerobic fitness (β=0.28, 95% CI 0.23 to 0.34), with larger effects for supervised interventions. Exercise effects on UBMS were larger during treatment, when supervised interventions included ≥3 sessions per week, when resistance exercises were included and when session duration was >60 min. Exercise effects on LBMS were larger for patients who were living alone, for supervised interventions including resistance exercise and when session duration was >60 min. Exercise effects on aerobic fitness were larger for younger patients and when supervised interventions included aerobic exercise.Exercise interventions during and following cancer treatment had small effects on UBMS, LBMS, LBMF and aerobic fitness. Demographic, intervention-related and exercise-related characteristics including age, marital status, intervention timing, delivery mode and frequency and type and time of exercise sessions moderated the exercise effect on UBMS, LBMS and aerobic fitness.
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000137585 7001_ $$aAltenburg, Teatske M$$b1
000137585 7001_ $$aBrug, Johannes$$b2
000137585 7001_ $$aMay, Anne M$$b3
000137585 7001_ $$avan Vulpen, Jonna K$$b4
000137585 7001_ $$aAaronson, Neil K$$b5
000137585 7001_ $$aArbane, Gill$$b6
000137585 7001_ $$aBohus, Martin$$b7
000137585 7001_ $$aCourneya, Kerry S$$b8
000137585 7001_ $$aDaley, Amanda J$$b9
000137585 7001_ $$aGalvao, Daniel A$$b10
000137585 7001_ $$aGarrod, Rachel$$b11
000137585 7001_ $$aGriffith, Kathleen A$$b12
000137585 7001_ $$aVan Harten, Wim H$$b13
000137585 7001_ $$aHayes, Sandra C$$b14
000137585 7001_ $$aHerrero-Román, Fernando$$b15
000137585 7001_ $$aKersten, Marie J$$b16
000137585 7001_ $$aLucia, Alejandro$$b17
000137585 7001_ $$aMcConnachie, Alex$$b18
000137585 7001_ $$avan Mechelen, Willem$$b19
000137585 7001_ $$aMutrie, Nanette$$b20
000137585 7001_ $$aNewton, Robert U$$b21
000137585 7001_ $$aNollet, Frans$$b22
000137585 7001_ $$aPotthoff, Karin$$b23
000137585 7001_ $$0P:(DE-He78)2def8f8594c8f797f5ed4398258c6cac$$aSchmidt, Martina$$b24
000137585 7001_ $$aSchmitz, Kathryn H$$b25
000137585 7001_ $$00000-0002-2411-6732$$aSchulz, Karl Heinz$$b26
000137585 7001_ $$aSonke, Gabe$$b27
000137585 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b28$$udkfz
000137585 7001_ $$aStuiver, Martijn M$$b29
000137585 7001_ $$aTaaffe, Dennis R$$b30
000137585 7001_ $$aThorsen, Lene$$b31
000137585 7001_ $$aTwisk, Jos W$$b32
000137585 7001_ $$aVelthuis, Miranda J$$b33
000137585 7001_ $$aWenzel, Jennifer$$b34
000137585 7001_ $$aWinters-Stone, Kerri M$$b35
000137585 7001_ $$aWiskemann, Joachim$$b36
000137585 7001_ $$aChin A Paw, Mai J$$b37
000137585 7001_ $$aBuffart, Laurien M$$b38
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