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000137587 1001_ $$00000-0003-2491-5099$$aPark, Jin Young$$b0
000137587 245__ $$aDietary folate intake and pancreatic cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition.
000137587 260__ $$aBognor Regis$$bWiley-Liss$$c2019
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000137587 520__ $$aPancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/d) compared with the lowest (<241 μg/d) was 0.81 (95% CI: 0.51, 1.31; Ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles (HR=4.42 (95% CI: 1.05, 18.62) for ≥353 μg/d vs. <241 μg/d, Ptrend = 0.01). Nonetheless, there was no significant interaction between smoking and dietary folate intake (Pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study. This article is protected by copyright. All rights reserved.
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000137587 7001_ $$aBueno-de-Mesquita, H Bas$$b1
000137587 7001_ $$aFerrari, Pietro$$b2
000137587 7001_ $$aWeiderpass, Elisabete$$b3
000137587 7001_ $$ade Batlle, Jordi$$b4
000137587 7001_ $$aTjønneland, Anne$$b5
000137587 7001_ $$00000-0002-9083-8960$$aKyro, Cecilie$$b6
000137587 7001_ $$aRebours, Vinciane$$b7
000137587 7001_ $$aBoutron-Ruault, Marie-Christine$$b8
000137587 7001_ $$aMancini, Francesca Romana$$b9
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000137587 7001_ $$aBoeing, Heiner$$b12
000137587 7001_ $$aTrichopoulou, Antonia$$b13
000137587 7001_ $$00000-0003-1441-897X$$aLa Vecchia, Carlo$$b14
000137587 7001_ $$aKritikou, Maria$$b15
000137587 7001_ $$aMasala, Giovanna$$b16
000137587 7001_ $$aPala, Valeria$$b17
000137587 7001_ $$aTumino, Rosario$$b18
000137587 7001_ $$aPanico, Salvatore$$b19
000137587 7001_ $$aPeeters, Petra H$$b20
000137587 7001_ $$aSkeie, Guri$$b21
000137587 7001_ $$aMerino, Susana$$b22
000137587 7001_ $$00000-0001-5256-0163$$aDuell, Eric J$$b23
000137587 7001_ $$aRodríguez-Barranco, Miguel$$b24
000137587 7001_ $$aDorronsoro, Miren$$b25
000137587 7001_ $$aChirlaque, Maria-Dolores$$b26
000137587 7001_ $$aArdanaz, Eva$$b27
000137587 7001_ $$aGylling, Björn$$b28
000137587 7001_ $$aSchneede, Jörn$$b29
000137587 7001_ $$aEricson, Ulrika$$b30
000137587 7001_ $$aSternby, Hanna$$b31
000137587 7001_ $$aKhaw, Kay-Tee$$b32
000137587 7001_ $$00000-0003-3345-7333$$aBradbury, Kathryn E$$b33
000137587 7001_ $$aHuybrechts, Inge$$b34
000137587 7001_ $$aAune, Dagfinn$$b35
000137587 7001_ $$aVineis, Paolo$$b36
000137587 7001_ $$aSlimani, Nadia$$b37
000137587 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.31830$$n7$$p1511-1521$$tInternational journal of cancer$$v144$$x0020-7136$$y2019
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