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@ARTICLE{Correia:137589,
      author       = {M. P. Correia and A. Stojanovic$^*$ and K. Bauer$^*$ and D.
                      Juraeva$^*$ and L.-O. Tykocinski and H.-M. Lorenz and B.
                      Brors$^*$ and A. Cerwenka$^*$},
      title        = {{D}istinct human circulating {NK}p30+{F}cε{RI}γ+{CD}8+
                      {T} cell population exhibiting high natural killer-like
                      antitumor potential.},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {115},
      number       = {26},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {DKFZ-2018-01469},
      pages        = {E5980 - E5989},
      year         = {2018},
      abstract     = {CD8+ T cells are considered prototypical cells of adaptive
                      immunity. Here, we uncovered a distinct CD8+ T cell
                      population expressing the activating natural killer (NK)
                      receptor NKp30 in the peripheral blood of healthy
                      individuals. We revealed that IL-15 could de novo induce
                      NKp30 expression in a population of CD8+ T cells and drive
                      their differentiation toward a broad innate transcriptional
                      landscape. The adaptor FcεRIγ was concomitantly induced
                      and was shown to be crucial to enable NKp30 cell-surface
                      expression and function in CD8+ T cells. FcεRIγ de novo
                      expression required promoter demethylation and was
                      accompanied by acquisition of the signaling molecule Syk and
                      the 'innate' transcription factor PLZF. IL-15-induced
                      NKp30+CD8+ T cells exhibited high NK-like antitumor activity
                      in vitro and were able to synergize with T cell receptor
                      signaling. Importantly, this population potently controlled
                      tumor growth in a preclinical xenograft mouse model. Our
                      study, while blurring the borders between innate and
                      adaptive immunity, reveals a unique NKp30+FcεRIγ+CD8+ T
                      cell population with high antitumor therapeutic potential.},
      keywords     = {FCER1G, human (NLM Chemicals) / NCR3 protein, human (NLM
                      Chemicals) / Natural Cytotoxicity Triggering Receptor 3 (NLM
                      Chemicals) / Receptors, Fc (NLM Chemicals)},
      cin          = {D080 / G200 / L101},
      ddc          = {000},
      cid          = {I:(DE-He78)D080-20160331 / I:(DE-He78)G200-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29895693},
      pmc          = {pmc:PMC6042091},
      doi          = {10.1073/pnas.1720564115},
      url          = {https://inrepo02.dkfz.de/record/137589},
}