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| 001 | 137589 | ||
| 005 | 20240229105111.0 | ||
| 024 | 7 | _ | |a 10.1073/pnas.1720564115 |2 doi |
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| 100 | 1 | _ | |a Correia, Margareta P |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential. |
| 260 | _ | _ | |a Washington, DC |c 2018 |b National Acad. of Sciences |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a CD8+ T cells are considered prototypical cells of adaptive immunity. Here, we uncovered a distinct CD8+ T cell population expressing the activating natural killer (NK) receptor NKp30 in the peripheral blood of healthy individuals. We revealed that IL-15 could de novo induce NKp30 expression in a population of CD8+ T cells and drive their differentiation toward a broad innate transcriptional landscape. The adaptor FcεRIγ was concomitantly induced and was shown to be crucial to enable NKp30 cell-surface expression and function in CD8+ T cells. FcεRIγ de novo expression required promoter demethylation and was accompanied by acquisition of the signaling molecule Syk and the 'innate' transcription factor PLZF. IL-15-induced NKp30+CD8+ T cells exhibited high NK-like antitumor activity in vitro and were able to synergize with T cell receptor signaling. Importantly, this population potently controlled tumor growth in a preclinical xenograft mouse model. Our study, while blurring the borders between innate and adaptive immunity, reveals a unique NKp30+FcεRIγ+CD8+ T cell population with high antitumor therapeutic potential. |
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| 650 | _ | 7 | |a FCER1G, human |2 NLM Chemicals |
| 650 | _ | 7 | |a NCR3 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Natural Cytotoxicity Triggering Receptor 3 |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Fc |2 NLM Chemicals |
| 700 | 1 | _ | |a Stojanovic, Ana |0 P:(DE-He78)6459232320662d60ee842fd348128d87 |b 1 |u dkfz |
| 700 | 1 | _ | |a Bauer, Katharina |0 P:(DE-He78)5b10e57ed1df98e2fd31edbdeed985ba |b 2 |u dkfz |
| 700 | 1 | _ | |a Juraeva, Dilafruz |0 P:(DE-He78)5482b9f7e4c4ff6a3a4d7c860a1bce61 |b 3 |u dkfz |
| 700 | 1 | _ | |a Tykocinski, Lars-Oliver |b 4 |
| 700 | 1 | _ | |a Lorenz, Hanns-Martin |b 5 |
| 700 | 1 | _ | |a Brors, Benedikt |0 P:(DE-He78)fc949170377b58098e46141d95c72661 |b 6 |u dkfz |
| 700 | 1 | _ | |a Cerwenka, Adelheid |0 P:(DE-He78)d2b4dd8bdffe4aaa0f5e30e91587766f |b 7 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1073/pnas.1720564115 |g Vol. 115, no. 26, p. E5980 - E5989 |0 PERI:(DE-600)1461794-8 |n 26 |p E5980 - E5989 |t Proceedings of the National Academy of Sciences of the United States of America |v 115 |y 2018 |x 1091-6490 |
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