%0 Journal Article
%A Rathke, Hendrik
%A Afshar-Oromieh, Ali
%A Giesel, Frederik Lars
%A Kremer, Christophe
%A Flechsig, Paul
%A Haufe, Sabine
%A Mier, Walter
%A Holland-Letz, Tim
%A De Bucourt, Maximilian
%A Armor, Thomas
%A Babich, John W
%A Haberkorn, Uwe
%A Kratochwil, Clemens
%T Intraindividual Comparison of 99mTc-Methylene Diphosphonate and Prostate-Specific Membrane Antigen Ligand 99mTc-MIP-1427 in Patients with Osseous Metastasized Prostate Cancer.
%J Journal of nuclear medicine
%V 59
%N 9
%@ 2159-662X
%C New York, NY
%I Soc.
%M DKFZ-2018-01490
%P 1373 - 1379
%D 2018
%X The objective of this study was to evaluate the rate of detection of bone metastases obtained with the prostate-specific membrane antigen (PSMA)-targeting tracer 99mTc-MIP-1427, as opposed to conventional bone scanning with 99mTc-methylene diphosphonate (99mTc-MDP), in a collective of patients with known advanced-stage osseous metastasized prostate cancer. Methods: Twenty-one patients with known metastatic disease were staged with both conventional bone scanning and PSMA ligand scintigraphy within a time frame of less than 10 d. Imaging included planar whole-body scanning and SPECT or SPECT/CT with 2 bed positions 3 h after injection of either 500-750 MBq of 99mTc-MIP-1427 or 600-750 MBq of 99mTc-MDP. Lesions were scored as typical tumor, equivocal (benign/malignant), or normal within a standard reporting schema divided into defined anatomic regions. Masked and consensus readings were performed with sequential unmasking: planar scans first, then SPECT/CT, the best evaluable comparator (including MRI), PET/CT, and follow-up examinations. Results: Eleven patients had PSMA-positive visceral metastases that were predictably not diagnosed with conventional bone scanning. However, SPECT/CT was required to distinguish between soft-tissue uptake and overlapping bone. Four patients had extensive 99mTc-MDP-negative bone marrow lesions. Seven patients had superscan characteristics on bone scans; in contrast, the extent of red marrow involvement was more evident on PSMA scans. Only 3 patients had equivalent results on bone scans and PSMA scans. In 16 patients, more suspect lesions were detected with PSMA scanning than with bone scanning. In 2 patients (10
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29371410
%R 10.2967/jnumed.117.200220
%U https://inrepo02.dkfz.de/record/137610