TY  - JOUR
AU  - Rathke, Hendrik
AU  - Afshar-Oromieh, Ali
AU  - Giesel, Frederik Lars
AU  - Kremer, Christophe
AU  - Flechsig, Paul
AU  - Haufe, Sabine
AU  - Mier, Walter
AU  - Holland-Letz, Tim
AU  - De Bucourt, Maximilian
AU  - Armor, Thomas
AU  - Babich, John W
AU  - Haberkorn, Uwe
AU  - Kratochwil, Clemens
TI  - Intraindividual Comparison of 99mTc-Methylene Diphosphonate and Prostate-Specific Membrane Antigen Ligand 99mTc-MIP-1427 in Patients with Osseous Metastasized Prostate Cancer.
JO  - Journal of nuclear medicine
VL  - 59
IS  - 9
SN  - 2159-662X
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2018-01490
SP  - 1373 - 1379
PY  - 2018
AB  - The objective of this study was to evaluate the rate of detection of bone metastases obtained with the prostate-specific membrane antigen (PSMA)-targeting tracer 99mTc-MIP-1427, as opposed to conventional bone scanning with 99mTc-methylene diphosphonate (99mTc-MDP), in a collective of patients with known advanced-stage osseous metastasized prostate cancer. Methods: Twenty-one patients with known metastatic disease were staged with both conventional bone scanning and PSMA ligand scintigraphy within a time frame of less than 10 d. Imaging included planar whole-body scanning and SPECT or SPECT/CT with 2 bed positions 3 h after injection of either 500-750 MBq of 99mTc-MIP-1427 or 600-750 MBq of 99mTc-MDP. Lesions were scored as typical tumor, equivocal (benign/malignant), or normal within a standard reporting schema divided into defined anatomic regions. Masked and consensus readings were performed with sequential unmasking: planar scans first, then SPECT/CT, the best evaluable comparator (including MRI), PET/CT, and follow-up examinations. Results: Eleven patients had PSMA-positive visceral metastases that were predictably not diagnosed with conventional bone scanning. However, SPECT/CT was required to distinguish between soft-tissue uptake and overlapping bone. Four patients had extensive 99mTc-MDP-negative bone marrow lesions. Seven patients had superscan characteristics on bone scans; in contrast, the extent of red marrow involvement was more evident on PSMA scans. Only 3 patients had equivalent results on bone scans and PSMA scans. In 16 patients, more suspect lesions were detected with PSMA scanning than with bone scanning. In 2 patients (10
LB  - PUB:(DE-HGF)16
C6  - pmid:29371410
DO  - DOI:10.2967/jnumed.117.200220
UR  - https://inrepo02.dkfz.de/record/137610
ER  -