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@ARTICLE{Rathke:137610,
      author       = {H. Rathke and A. Afshar-Oromieh and F. L. Giesel and C.
                      Kremer and P. Flechsig and S. Haufe and W. Mier and T.
                      Holland-Letz$^*$ and M. De Bucourt and T. Armor and J. W.
                      Babich and U. Haberkorn$^*$ and C. Kratochwil},
      title        = {{I}ntraindividual {C}omparison of 99m{T}c-{M}ethylene
                      {D}iphosphonate and {P}rostate-{S}pecific {M}embrane
                      {A}ntigen {L}igand 99m{T}c-{MIP}-1427 in {P}atients with
                      {O}sseous {M}etastasized {P}rostate {C}ancer.},
      journal      = {Journal of nuclear medicine},
      volume       = {59},
      number       = {9},
      issn         = {2159-662X},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2018-01490},
      pages        = {1373 - 1379},
      year         = {2018},
      abstract     = {The objective of this study was to evaluate the rate of
                      detection of bone metastases obtained with the
                      prostate-specific membrane antigen (PSMA)-targeting tracer
                      99mTc-MIP-1427, as opposed to conventional bone scanning
                      with 99mTc-methylene diphosphonate (99mTc-MDP), in a
                      collective of patients with known advanced-stage osseous
                      metastasized prostate cancer. Methods: Twenty-one patients
                      with known metastatic disease were staged with both
                      conventional bone scanning and PSMA ligand scintigraphy
                      within a time frame of less than 10 d. Imaging included
                      planar whole-body scanning and SPECT or SPECT/CT with 2 bed
                      positions 3 h after injection of either 500-750 MBq of
                      99mTc-MIP-1427 or 600-750 MBq of 99mTc-MDP. Lesions were
                      scored as typical tumor, equivocal (benign/malignant), or
                      normal within a standard reporting schema divided into
                      defined anatomic regions. Masked and consensus readings were
                      performed with sequential unmasking: planar scans first,
                      then SPECT/CT, the best evaluable comparator (including
                      MRI), PET/CT, and follow-up examinations. Results: Eleven
                      patients had PSMA-positive visceral metastases that were
                      predictably not diagnosed with conventional bone scanning.
                      However, SPECT/CT was required to distinguish between
                      soft-tissue uptake and overlapping bone. Four patients had
                      extensive 99mTc-MDP-negative bone marrow lesions. Seven
                      patients had superscan characteristics on bone scans; in
                      contrast, the extent of red marrow involvement was more
                      evident on PSMA scans. Only 3 patients had equivalent
                      results on bone scans and PSMA scans. In 16 patients, more
                      suspect lesions were detected with PSMA scanning than with
                      bone scanning. In 2 patients $(10\%),$ a PSMA-negative tumor
                      phenotype was present. Conclusion: PSMA scanning provided a
                      clear advantage over bone scanning by reducing the number of
                      equivocal findings in most patients. SPECT/CT was pivotal
                      for differentiating bone metastases from extraosseous tumor
                      lesions.},
      cin          = {C060 / E060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E060-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29371410},
      doi          = {10.2967/jnumed.117.200220},
      url          = {https://inrepo02.dkfz.de/record/137610},
}